Inoue O, Seiji K, Ishihara N, Kumai M, Ikeda M
Toxicol Lett. 1984 Nov;23(2):249-57. doi: 10.1016/0378-4274(84)90134-6.
Rats (Fisher, Wistar, Donryu and Sprague-Dawley strains) were exposed to 5 approximately 3500 ppm toluene for 8 h, and urine samples were analyzed for hippuric acid and cresols. While hippuric acid increased in proportion to the exposure concentration, a sharp increase in o-cresol excretion was observed at high toluene concentrations so that the o-cresol/hippuric acid ratio was elevated after 500 approximately 3500 ppm exposures. Changes in the p-cresol: hippuric acid ratio were less marked. There were strain differences in toluene metabolism. Fisher rats were highest and Sprague-Dawley rats lowest in o-cresol excretion and in the o-cresol: hippuric acid ratio, whereas Wistar rats excreted p-cresol most abundantly.
将大鼠（费希尔、威斯塔、唐育和斯普拉格-道利品系）暴露于约3500 ppm的甲苯中5次，每次8小时，然后分析尿液样本中的马尿酸和甲酚。虽然马尿酸的增加与暴露浓度成比例，但在高甲苯浓度下观察到邻甲酚排泄量急剧增加，因此在500至约3500 ppm暴露后，邻甲酚/马尿酸比值升高。对甲酚：马尿酸比值的变化不太明显。甲苯代谢存在品系差异。费希尔大鼠的邻甲酚排泄量和邻甲酚：马尿酸比值最高，斯普拉格-道利大鼠最低，而威斯塔大鼠排泄对甲酚最为丰富。
