甲苯的实验性暴露：对人体中甲苯酚形成的进一步思考。
Experimental exposure to toluene: further consideration of cresol formation in man.
作者信息
Woiwode W, Drysch K
出版信息
Br J Ind Med. 1981 May;38(2):194-7. doi: 10.1136/oem.38.2.194.
Abstract
In two separate experiments 10 healthy men each were exposed at rest in an exposure chamber to about 200 ppm toluene in the air. Hippuric acid, o-, m-, p-cresol, and phenol in urine were detected by capillary gas chromatography at the beginning and at the end of exposure, and at variable times after the cessation of exposure. In addition toluene in blood was determined at the same intervals. The results indicate that in addition to hippuric acid, o-, m-, p-cresol are metabolites of toluene; the detoxication lasting 24 hours at least.
摘要
在两项独立实验中，每组10名健康男性在暴露舱内静息状态下暴露于空气中约200 ppm的甲苯环境。在暴露开始时、结束时以及暴露停止后的不同时间，通过毛细管气相色谱法检测尿液中的马尿酸、邻甲酚、间甲酚、对甲酚和苯酚。同时在相同时间间隔测定血液中的甲苯含量。结果表明，除马尿酸外，邻甲酚、间甲酚、对甲酚也是甲苯的代谢产物；解毒过程至少持续24小时。
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本文引用的文献
1
Significance of urinary hippuric acid determination as an index of toluene exposure.
Br J Ind Med. 1969 Jul;26(3):244-6. doi: 10.1136/oem.26.3.244.
2
Urinary excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene as a test of exposure.
Br J Ind Med. 1970 Jan;27(1):43-50. doi: 10.1136/oem.27.1.43.
3
Metabolism of industrial solvents.
IMS Ind Med Surg. 1970 May;39(5):61-4.
4
5
Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine.
Arch Toxicol. 1979 Dec;43(2):93-8. doi: 10.1007/BF00333615.
6
Experimental human exposure to toluene, III. Urinary hippuric acid excretion as a measure of individual solvent uptake.
Int Arch Occup Environ Health. 1979 Mar 7;43(1):53-62. doi: 10.1007/BF00454280.
7
Urinary excretion of hippuric acid and m-methylhippuric acid after administration of toluene and m-xylene mixture to rats.
Int Arch Occup Environ Health. 1979 Mar 7;43(1):45-51. doi: 10.1007/BF00454279.
8
[Occupational chronic exposure to organic solvents V. chromatographic methods for the determination of phenols in urine (author's transl)].
Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):257-8. doi: 10.1007/BF00377780.
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