Cok Ismet, Dagdelen Ayfer, Gökçe Esin
Faculty of Pharmacy, Department of Toxicology, Gazi University, Ankara, Turkey.
Biomarkers. 2003 Mar-Apr;8(2):119-27. doi: 10.1080/1354750031000119398.
In this study, groups exposed to toluene either intentionally (glue sniffers) or unintentionally (shoe-workers) were compared. The groups were evaluated in terms of urinary levels of the toluene metabolites hippuric acid and o-cresol. Results were also compared with control values. Hippuric acid levels were determined by high performance liquid chromatography and o-cresol levels by gas liquid chromatography. The levels of hippuric acid and o-cresol were found to be statistically significantly higher in glue sniffers than in shoe-workers (p <0.001) or controls (p <0.001). In addition, the differences between the levels of urinary hippuric acid and o-cresol in the shoe-workers and in the controls were statistically significant (p <0.05 and p <0.001, respectively). These results suggest that extremely high levels of urinary hippuric acid and o-cresol indicate massive exposure to toluene.
在本研究中，对有意接触甲苯的群体（胶水吸食者）和无意接触甲苯的群体（鞋厂工人）进行了比较。根据甲苯代谢产物马尿酸和邻甲酚的尿液水平对这些群体进行了评估。结果也与对照值进行了比较。马尿酸水平通过高效液相色谱法测定，邻甲酚水平通过气液色谱法测定。发现胶水吸食者的马尿酸和邻甲酚水平在统计学上显著高于鞋厂工人（p<0.001）或对照组（p<0.001）。此外，鞋厂工人与对照组尿液中马尿酸和邻甲酚水平的差异具有统计学意义（分别为p<0.05和p<0.001）。这些结果表明，尿液中极高水平的马尿酸和邻甲酚表明大量接触了甲苯。
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