Ushijima M, Tsuneyoshi M, Enjoji M
Acta Pathol Jpn. 1984 Sep;34(5):991-1001. doi: 10.1111/j.1440-1827.1984.tb07630.x.
This clinicopathologic study concerns 62 patients with one of the Dupuytren type fibromatoses. Of the 62 patients, 42 had the lesion in the palm (palmar fibromatosis), 12 in the sole (plantar fibromatosis), 2 in the penis (penile fibromatosis), and 6 in the ectopic locations, the dorsal aspect of the hand in 3 patients, the dorsum of the fingers in 2, and the forearm in 1. The clinically palpable nodules were histologically classified into those of the following three phases, according to LUCK'S classification: proliferative phase (27), involutional phase (23), and residual phase (12). In addition to fibroblastic proliferation, the lesion of the proliferative phase exhibited vascular features consisting of one or more layers of cells with oval nuclei around the vessels within the nodule. In the lesions of the late proliferative and involutional phase, the intracytoplasmic fine filaments were visible in cells compatible with myofibroblasts by Masson's trichrome stain. The nuclei of the elemental fibroblasts in the same phases were often crossed transversely by one or more fine basophilic lines.
这项临床病理研究涉及62例患有杜普伊特伦型纤维瘤病的患者。在这62例患者中，42例病变位于手掌（掌部纤维瘤病），12例位于足底（跖部纤维瘤病），2例位于阴茎（阴茎纤维瘤病），6例位于异位部位，3例在手背，2例在手指背侧，1例在前臂。根据卢克分类法，临床上可触及的结节在组织学上分为以下三个阶段：增殖期（27例）、退化期（23例）和残留期（12例）。除了成纤维细胞增殖外，增殖期病变还表现出血管特征，即在结节内血管周围有一层或多层椭圆形核的细胞。在增殖后期和退化期的病变中，通过Masson三色染色法，在与肌成纤维细胞相符的细胞中可见胞浆内细丝。同一阶段的原始成纤维细胞核常被一条或多条细嗜碱性线横向穿过。
