Leo M A, Lowe N, Lieber C S
Am J Clin Nutr. 1984 Dec;40(6):1131-6. doi: 10.1093/ajcn/40.6.1131.
Eleven patients with moderate drug-induced liver changes were found to have extremely low hepatic vitamin A levels (less than 10% of normal). Their serum vitamin A, retinol-binding protein, and transthyretin were only slightly affected. In rats, two representative drugs (phenobarbital and methylcholanthrene) produced a significant depression of hepatic vitamin A, whereas plasma vitamin A levels remained normal. The livers of drug-treated animals showed no abnormalities except for the expected proliferation of the smooth endoplasmic reticulum and induction of microsomal enzymes and cytochrome P-450 (phenobarbital) and P-448 (methylcholanthrene). These findings suggest that the decrease in hepatic vitamin A may be secondary, at least in part, to enhanced microsomal metabolism.
发现11例有中度药物性肝脏改变的患者肝脏维生素A水平极低（低于正常水平的10%）。他们的血清维生素A、视黄醇结合蛋白和转甲状腺素蛋白仅受到轻微影响。在大鼠中，两种代表性药物（苯巴比妥和甲基胆蒽）可使肝脏维生素A显著降低，而血浆维生素A水平仍保持正常。药物处理动物的肝脏除了出现预期的滑面内质网增生以及微粒体酶和细胞色素P-450（苯巴比妥）和P-448（甲基胆蒽）的诱导外，未显示出异常。这些发现表明，肝脏维生素A的降低至少部分可能是微粒体代谢增强的继发结果。
