Morris J G, Ferreccio C, Garcia J, Lobos H, Black R E, Rodriguez H, Levine M M
Am J Trop Med Hyg. 1984 Nov;33(6):1198-202. doi: 10.4269/ajtmh.1984.33.1198.
We obtained clinical, epidemiological, and laboratory data (including three stool cultures) from 155 (96%) of 161 household contacts of 24 patients less than 16 years old with culture-confirmed typhoid fever; these 24 patients represented approximately 40% of such patients seen in three hospitals in Santiago during a 12-week period. A chronic typhoid carrier was identified in only one household, with concurrent or secondary cases seen in two other households. When index cases were matched with household members nearest in age, no specific risk factors for illness could be identified. There was evidence of generalized exposure to enteric pathogens within these households, with nine persons from seven different households culture-positive for non-typhoidal Salmonella, and nine, from eight different households, culture-positive for Shigella; transmission of these pathogens within households did not appear to be common since no household had more than one family member with the same serotype or species of either pathogen.
我们从24名16岁以下血培养确诊为伤寒热患者的161名家庭接触者中的155名（96%）获取了临床、流行病学和实验室数据（包括三次粪便培养）；这24名患者约占圣地亚哥三家医院在12周内所见此类患者的40%。仅在一个家庭中发现了一名慢性伤寒携带者，另外两个家庭出现了并发或继发病例。当将索引病例与年龄最接近的家庭成员进行匹配时，未发现特定的发病危险因素。有证据表明这些家庭中普遍接触肠道病原体，七个不同家庭的九人非伤寒沙门氏菌培养呈阳性，八个不同家庭的九人志贺氏菌培养呈阳性；这些病原体在家庭内的传播似乎并不常见，因为没有一个家庭有不止一名家庭成员感染相同血清型或种类的任何一种病原体。
