Blackmon B B, Mahaffey J E, Baker J D
Anesth Analg. 1984 Dec;63(12):1116-20.
The current study was undertaken to determine whether the same doses (mg/kg) of 5 mg/ml of midazolam hydrochloride and 2.5 mg/ml of midazolam maleate are required for the induction of anesthesia. Midazolam hydrochloride and midazolam maleate were compared in a prospective double-blind fashion, in which both cardiopulmonary and sedative effects were measured in 12 patients who required repeated anesthesia for serial gynecologic radium insertions. The results showed no significant differences in clinical activity between midazolam maleate and the newer preparation, midazolam hydrochloride. Time of onset, recovery time, lack of venous irritation, and stability of cardiopulmonary variables when using the hydrochloride were essentially the same with the maleate.
本研究旨在确定诱导麻醉时，5mg/ml盐酸咪达唑仑和2.5mg/ml马来酸咪达唑仑是否需要相同剂量（mg/kg）。采用前瞻性双盲方式对盐酸咪达唑仑和马来酸咪达唑仑进行比较，在12例因妇科镭植入需要反复麻醉的患者中测量了心肺和镇静效果。结果显示，马来酸咪达唑仑与较新制剂盐酸咪达唑仑在临床活性上无显著差异。使用盐酸盐时的起效时间、恢复时间、无静脉刺激以及心肺变量的稳定性与马来酸盐基本相同。
