咪达唑仑作为区域麻醉中的镇静剂。初步结果。
Midazolam as a sedative on regional anesthesia. Preliminary results.
作者信息
Driessen J J, Booij L H, Vree T B, Crul J F
出版信息
Arzneimittelforschung. 1981;31(12a):2245-7.
PMID:7199328
Abstract
Diazepam is widely used as a sedative for loco-regional anesthesia. The venous irritation and long duration of action and hangover may be a drawback. We compared 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum), a new water-soluble benzodiazepine, with diazepam for cardio-respiratory changes, onset time, duration of action, amnesia and venous irritation after a single i.v. shot in loco-regional anesthesia.
摘要
地西泮被广泛用作局部区域麻醉的镇静剂。静脉刺激、作用时间长及宿醉反应可能是其缺点。我们将一种新型水溶性苯二氮䓬类药物8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-a][1,4]苯二氮䓬（咪达唑仑，Ro 21-3981，多美康）与地西泮进行比较，观察在局部区域麻醉单次静脉注射后两者对心肺变化、起效时间、作用持续时间、遗忘作用及静脉刺激的影响。
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