Adessi G L, Prost O, Agnani G, Petitjean A, Burnod J
Arch Gynecol. 1984;236(1):13-8. doi: 10.1007/BF02114864.
We investigated the activity of estrone sulfatase in normal and pathological endometrium. In normal endometrium, the estrone sulfatase activity [pmol E1 X min-1 X (mg prot)-1] was 23.13 +/- 8.44 (mean +/- SD). An increase (p less than 0.01) of estrone sulfatase activity (62.81 +/- 21.97) was noted in mild endometrial hyperplasia. In focal hyperplasia (when the measurements were performed in the normal endometrial biopsies) such an increase was not noted (19.10 +/- 5.33). Estrone sulfatase activities of moderate hyperplasia (25.30 +/- 11.40) and endometrial neoplasia (30.30 +/- 9.57) were in the same range as in normal endometrium. Treatment with progestagen simultaneously reduced hyperplasia and estrone sulfatase activity. But when morphologically abnormal endometrium persisted after treatment, estrone sulfatase activity remained increased. The increase of estrone sulfatase activity appeared to be specific to mild endometrial hyperplasia. The role of estrone sulfatase in the pathogenesis of endometrial hyperplasia is discussed.
我们研究了正常及病理状态下子宫内膜中硫酸雌酮酶的活性。在正常子宫内膜中，硫酸雌酮酶活性[pmol E1×min⁻¹×(mg蛋白)⁻¹]为23.13±8.44（均值±标准差）。在轻度子宫内膜增生中，硫酸雌酮酶活性增加（p＜0.01）（62.81±21.97）。在局灶性增生中（当在正常子宫内膜活检组织中进行测量时）未观察到这种增加（19.10±5.33）。中度增生（25.30±11.40）和子宫内膜肿瘤（30.30±9.57）的硫酸雌酮酶活性与正常子宫内膜处于相同范围。孕激素治疗同时降低了增生程度和硫酸雌酮酶活性。但当治疗后形态学异常的子宫内膜持续存在时，硫酸雌酮酶活性仍升高。硫酸雌酮酶活性的增加似乎是轻度子宫内膜增生所特有的。本文讨论了硫酸雌酮酶在子宫内膜增生发病机制中的作用。
