Sommer A, Quigley H A, Robin A L, Miller N R, Katz J, Arkell S
Arch Ophthalmol. 1984 Dec;102(12):1766-71. doi: 10.1001/archopht.1984.01040031430017.
More than 1,400 eyes with either ocular hypertension glaucomatous visual field loss, or normal pressures and fields (controls) were studied prospectively in standardized, masked fashion. The appearance of the nerve fiber layer was evaluated independently from red-free photographs with the discs blocked-out by two observers. The vast majority of photographs could be evaluated, the proportion varying with the observer and with the age and clinical status of the subject. Sensitivity (proportion of glaucomatous eyes with nerve fiber defects) and specificity (proportion of normal control eyes without defects) averaged 80% to 94%, varying with the observer and with the age, race, and severity of field loss. In two thirds of presumed false-positive eyes, but only 5% of true-positive eyes, the abnormalities were limited to focal slitlike defects. The prevalence of nerve fiber defects in eyes with elevated pressure and normal visual fields was similar to that in control eyes, approximately 10%. However, the proportion of eyes in which these defects included diffuse loss was considerably higher among the hypertensive eyes.
对1400多只眼睛进行了前瞻性研究，这些眼睛要么患有高眼压性青光眼视野缺损，要么眼压和视野正常（对照组），研究采用标准化的、盲法进行。两名观察者独立于无赤光照片评估神经纤维层的外观，照片中的视盘已被遮挡。绝大多数照片都能得到评估，评估比例因观察者以及受试者的年龄和临床状况而异。敏感性（患有神经纤维缺损的青光眼眼的比例）和特异性（无缺损的正常对照眼的比例）平均为80%至94%，因观察者以及年龄、种族和视野缺损严重程度而异。在三分之二的疑似假阳性眼中，但仅5%的真阳性眼中，异常仅限于局灶性裂隙样缺损。眼压升高且视野正常的眼中神经纤维缺损的患病率与对照眼中相似，约为10%。然而，在高血压眼中，这些缺损包括弥漫性丧失的眼睛比例要高得多。
