放线菌酮可阻止饥饿状态下大鼠肝脏肉碱棕榈酰转移酶1活性的变化。
Cycloheximide blocks changes in rat liver carnitine palmitoyltransferase 1 activity in starvation.
作者信息
Saggerson E D, Bird M I, Carpenter C A, Winter K A, Wright J J
出版信息
Biochem J. 1984 Nov 15;224(1):201-6. doi: 10.1042/bj2240201.
Abstract
Starvation (24h) increased the maximum activity of carnitine palmitoyltransferase 1 in rat liver and increased the concentration of malonyl-CoA required to cause 50% inhibition of the enzyme (I50). Re-feeding (24h) with a standard cube diet or a high-carbohydrate diet reversed both of these changes, whereas re-feeding with a high-fat diet did not. Administration of cycloheximide (200 micrograms/100 g body wt.) blocked the increases in carnitine palmitoyltransferase 1 activity and I50 on starvation. It is suggested that increase in carnitine palmitoyltransferase 1 activity in starvation may involve synthesis of new enzyme.
摘要
饥饿（24小时）可提高大鼠肝脏中肉碱棕榈酰转移酶1的最大活性，并增加导致该酶50%抑制率（I50）所需的丙二酰辅酶A浓度。用标准颗粒饲料或高碳水化合物饲料再喂养（24小时）可逆转这两种变化，而用高脂肪饲料再喂养则不能。给予环己酰亚胺（200微克/100克体重）可阻断饥饿时肉碱棕榈酰转移酶1活性和I50的增加。提示饥饿时肉碱棕榈酰转移酶1活性增加可能涉及新酶的合成。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria.禁食和丙二酰辅酶A对完整大鼠肝脏线粒体中肉碱棕榈酰转移酶和肉碱辛酰转移酶动力学的影响。
FEBS Lett. 1981 Sep 28;132(2):166-8. doi: 10.1016/0014-5793(81)81152-0.
3
The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.禁食对肝脏肉碱棕榈酰转移酶活性的影响及其被丙二酰辅酶A的抑制作用。
Biochim Biophys Acta. 1981 Sep 24;665(3):628-31. doi: 10.1016/0005-2760(81)90282-4.
4
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5
Effects of thyroidectomy and starvation on the activity and properties of hepatic carnitine palmitoyltransferase.甲状腺切除术和饥饿对肝脏肉碱棕榈酰转移酶活性及特性的影响。
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6
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Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.
7
Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.放线菌酮抑制蛋白质合成对泌乳大鼠乳腺和肝脏脂肪生成的影响。
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J Biochem. 1982 May;91(5):1739-48. doi: 10.1093/oxfordjournals.jbchem.a133866.
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The outer carnitine palmitoyltransferase and regulation of fatty acid metabolism in rat liver in different thyroid states.大鼠肝脏中不同甲状腺状态下的外源性肉碱棕榈酰转移酶与脂肪酸代谢调控
Biochim Biophys Acta. 1983 Feb 7;750(2):244-52. doi: 10.1016/0005-2760(83)90025-5.
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