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1
Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。
Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.
2
Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.进食或饥饿大鼠肝脏分离线粒体中丙二酰辅酶A对肉碱棕榈酰转移酶I抑制作用的时间依赖性。该酶对丙二酰辅酶A的低亲和力和高亲和力状态之间转变的证据。
Biochem J. 1984 Mar 1;218(2):379-86. doi: 10.1042/bj2180379.
3
Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.丙二酰辅酶A对肉碱棕榈酰转移酶抑制作用中的滞后效应参与情况。
Biochem J. 1984 Dec 15;224(3):1015-8. doi: 10.1042/bj2241015.
4
Reversible sensitization and desensitization of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in isolated rat liver mitochondria. Significance for the mechanism of malonyl-CoA-induced sensitization.肉碱棕榈酰转移酶I在离体大鼠肝脏线粒体中对丙二酰辅酶A抑制作用的可逆性致敏和脱敏。对丙二酰辅酶A诱导致敏机制的意义。
Biochem J. 1983 Sep 15;214(3):1027-30. doi: 10.1042/bj2141027.
5
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
Biochem J. 1983 May 15;212(2):521-4. doi: 10.1042/bj2120521.
6
Re-evaluation of the interaction of malonyl-CoA with the rat liver mitochondrial carnitine palmitoyltransferase system by using purified outer membranes.利用纯化的外膜重新评估丙二酰辅酶A与大鼠肝脏线粒体肉碱棕榈酰转移酶系统的相互作用。
Biochem J. 1990 Apr 1;267(1):85-90. doi: 10.1042/bj2670085.
7
Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations.在短期肝细胞培养中，乙醇会增加肉碱棕榈酰转移酶I对丙二酰辅酶A抑制作用的敏感性。
Biochim Biophys Acta. 1989 Apr 26;1002(3):405-8. doi: 10.1016/0005-2760(89)90358-5.
8
Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.酮症糖尿病大鼠中肉碱棕榈酰转移酶对丙二酰辅酶A抑制作用的敏感性改变。
Biochem J. 1984 Apr 1;219(1):337-9. doi: 10.1042/bj2190337.
9
Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.肉碱棕榈酰转移酶的滞后行为。丙二酰辅酶A预温育的影响。
Biochem J. 1986 Jun 15;236(3):917-9. doi: 10.1042/bj2360917.
10
Response to starvation of hepatic carnitine palmitoyltransferase activity and its regulation by malonyl-CoA. Sex differences and effects of pregnancy.肝脏肉碱棕榈酰转移酶活性对饥饿的反应及其受丙二酰辅酶A的调节。性别差异及妊娠的影响。
Biochem J. 1982 Dec 15;208(3):673-8. doi: 10.1042/bj2080673.

引用本文的文献

1
Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes.关于大鼠肝细胞中冈田酸通过磷酸化直接参与肉碱棕榈酰转移酶激活的证据不足。
Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):693-9. doi: 10.1042/bj3000693.
2
Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.进食或饥饿大鼠肝脏分离线粒体中丙二酰辅酶A对肉碱棕榈酰转移酶I抑制作用的时间依赖性。该酶对丙二酰辅酶A的低亲和力和高亲和力状态之间转变的证据。
Biochem J. 1984 Mar 1;218(2):379-86. doi: 10.1042/bj2180379.
3
Reversible sensitization and desensitization of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in isolated rat liver mitochondria. Significance for the mechanism of malonyl-CoA-induced sensitization.肉碱棕榈酰转移酶I在离体大鼠肝脏线粒体中对丙二酰辅酶A抑制作用的可逆性致敏和脱敏。对丙二酰辅酶A诱导致敏机制的意义。
Biochem J. 1983 Sep 15;214(3):1027-30. doi: 10.1042/bj2141027.
4
Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.丙二酰辅酶A对肉碱棕榈酰转移酶抑制作用中的滞后效应参与情况。
Biochem J. 1984 Dec 15;224(3):1015-8. doi: 10.1042/bj2241015.
5
Binding of malonyl-CoA to isolated mitochondria. Evidence for high- and low-affinity sites in liver and heart and relationship to inhibition of carnitine palmitoyltransferase activity.丙二酰辅酶A与分离的线粒体的结合。肝脏和心脏中高亲和力和低亲和力位点的证据及其与肉碱棕榈酰转移酶活性抑制的关系。
Biochem J. 1984 Sep 15;222(3):639-47. doi: 10.1042/bj2220639.
6
Changes in the ability of malonyl-CoA to inhibit carnitine palmitoyltransferase I activity and to bind to rat liver mitochondria during incubation in vitro. Differences in binding at 0 degree C and 37 degrees C with a fixed concentration of malonyl-CoA.体外孵育期间丙二酰辅酶A抑制肉碱棕榈酰转移酶I活性及与大鼠肝脏线粒体结合能力的变化。在0℃和37℃下，固定浓度的丙二酰辅酶A结合情况的差异。
Biochem J. 1984 Sep 1;222(2):335-42. doi: 10.1042/bj2220335.
7
A cold-clamping technique for the rapid sampling of rat liver for studies on enzymes in separate cell fractions. Suitability for the study of enzymes regulated by reversible phosphorylation-dephosphorylation.一种用于快速采集大鼠肝脏样本以研究不同细胞组分中酶的冷钳夹技术。适用于研究受可逆磷酸化-去磷酸化调节的酶。
Biochem J. 1984 Jun 15;220(3):733-8. doi: 10.1042/bj2200733.
8
Altered release of carnitine palmitoyltransferase activity by digitonin from liver mitochondria of rats in different physiological states.不同生理状态下大鼠肝脏线粒体中洋地黄皂苷对肉碱棕榈酰转移酶活性释放的影响。
Biochem J. 1985 Sep 1;230(2):389-94. doi: 10.1042/bj2300389.
9
Effects of the mode of addition of acyl-CoA on the initial rate of formation of acylcarnitine in the presence of carnitine by intact rat liver mitochondria in vitro.体外培养的完整大鼠肝线粒体中，酰基辅酶A添加方式对肉碱存在时酰基肉碱初始形成速率的影响。
Biochem J. 1985 Jul 1;229(1):273-5. doi: 10.1042/bj2290273.
10
Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation.绵羊和大鼠肝脏线粒体中长链脂肪酸的氧化代谢。有证据表明绵羊通过限制亚油酸的氧化来保存它。
Biochem J. 1985 Jan 1;225(1):233-7. doi: 10.1042/bj2250233.

本文引用的文献

1
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats.实验条件在评估肝脏肉碱酰基转移酶丙二酸单酰辅酶A敏感性中的重要性。对喂食和饥饿大鼠的研究。
Biochem J. 1981 Nov 15;200(2):217-23. doi: 10.1042/bj2000217.
2
Regulation of hepatic fatty acid metabolism. The activities of mitochondrial and microsomal acyl-CoA:sn-glycerol 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketone bodies and long-chain acyl-CoA esters in livers of fed or starved pregnant, lactating and weaned rats.肝脏脂肪酸代谢的调节。喂食或饥饿的怀孕、哺乳和断奶大鼠肝脏中线粒体和微粒体酰基辅酶A：sn-甘油3-磷酸O-酰基转移酶的活性以及丙二酰辅酶A、非酯化和酯化肉碱、甘油3-磷酸、酮体和长链酰基辅酶A酯的浓度。
Biochem J. 1981 Jul 15;198(1):75-83. doi: 10.1042/bj1980075.
3
Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria.禁食和丙二酰辅酶A对完整大鼠肝脏线粒体中肉碱棕榈酰转移酶和肉碱辛酰转移酶动力学的影响。
FEBS Lett. 1981 Sep 28;132(2):166-8. doi: 10.1016/0014-5793(81)81152-0.
4
Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。
Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.

在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。

Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.

作者信息

Zammit V A

出版信息

Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.

DOI:10.1042/bj2100953
PMID:6870813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1154313/
Abstract

Carnitine palmitoyltransferase I in rat liver mitochondria preincubated with malonyl-CoA was more sensitive to inhibition by malonyl-CoA than was the enzyme in mitochondria preincubated in the absence of malonyl-CoA. For carnitine palmitoyltransferase I in mitochondria from starved animals this increase also resulted in the enzyme becoming significantly more sensitive than that in mitochondria assayed immediately after their isolation. Concentrations of malonyl-CoA that induced half the maximal degree of sensitization observed were 1-3 microM.

摘要

与在无丙二酸单酰辅酶A的情况下预孵育的线粒体中的酶相比，在与丙二酸单酰辅酶A预孵育的大鼠肝脏线粒体中，肉碱棕榈酰转移酶I 对丙二酸单酰辅酶A的抑制作用更敏感。对于饥饿动物线粒体中的肉碱棕榈酰转移酶I，这种增加还导致该酶比分离后立即测定的线粒体中的酶明显更敏感。诱导观察到的最大致敏程度一半的丙二酸单酰辅酶A浓度为1-3微摩尔。