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在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。

Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.

作者信息

Robinson I N, Zammit V A

出版信息

Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.

DOI:10.1042/bj2060177
PMID:7126192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1158567/
Abstract

The sensitivity of carnitine acyltransferase I (EC 2.3.1.21) activity to malonyl-CoA inhibition in rat liver mitochondria isolated from animals in various physiological states was quantitatively proportional to the hepatic malonyl-CoA concentration in vivo. It is suggested that this relationship between the two parameters could result in a potent amplification mechanism for the reciprocal regulation of fatty acid synthesis and oxidation.

摘要

从处于不同生理状态的动物分离得到的大鼠肝脏线粒体中，肉碱脂酰转移酶I（EC 2.3.1.21）活性对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度呈定量比例关系。有人提出，这两个参数之间的这种关系可能导致脂肪酸合成与氧化相互调节的有效放大机制。

相似文献

1
Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。
Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.
2
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
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3
Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。
Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.
4
Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.酮症糖尿病大鼠中肉碱棕榈酰转移酶对丙二酰辅酶A抑制作用的敏感性改变。
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5
Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.进食或饥饿大鼠肝脏分离线粒体中丙二酰辅酶A对肉碱棕榈酰转移酶I抑制作用的时间依赖性。该酶对丙二酰辅酶A的低亲和力和高亲和力状态之间转变的证据。
Biochem J. 1984 Mar 1;218(2):379-86. doi: 10.1042/bj2180379.
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Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations.在短期肝细胞培养中，乙醇会增加肉碱棕榈酰转移酶I对丙二酰辅酶A抑制作用的敏感性。
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7
Reversible sensitization and desensitization of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in isolated rat liver mitochondria. Significance for the mechanism of malonyl-CoA-induced sensitization.肉碱棕榈酰转移酶I在离体大鼠肝脏线粒体中对丙二酰辅酶A抑制作用的可逆性致敏和脱敏。对丙二酰辅酶A诱导致敏机制的意义。
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8
Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis.丙二酰辅酶A对绵羊肝脏线粒体中肉碱棕榈酰转移酶活性的调节，绵羊肝脏是脂肪酸合成能力较低的组织。
Biochem J. 1985 Nov 15;232(1):177-82. doi: 10.1042/bj2320177.
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Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.肉碱棕榈酰转移酶I。丙二酰辅酶A对肝脏脂肪酸氧化的抑制位点。
J Biol Chem. 1978 Jun 25;253(12):4128-36.
10
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Biochem J. 1984 Dec 15;224(3):1015-8. doi: 10.1042/bj2241015.

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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria.胰高血糖素处理以及处女鼠和泌乳期大鼠饥饿对离体肝线粒体中辛酰-L-肉碱和辛酸氧化速率的影响。
Biochem J. 1980 Aug 15;190(2):293-300. doi: 10.1042/bj1900293.
3
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats.实验条件在评估肝脏肉碱酰基转移酶丙二酸单酰辅酶A敏感性中的重要性。对喂食和饥饿大鼠的研究。
Biochem J. 1981 Nov 15;200(2):217-23. doi: 10.1042/bj2000217.
4
Regulation of hepatic fatty acid metabolism. The activities of mitochondrial and microsomal acyl-CoA:sn-glycerol 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketone bodies and long-chain acyl-CoA esters in livers of fed or starved pregnant, lactating and weaned rats.肝脏脂肪酸代谢的调节。喂食或饥饿的怀孕、哺乳和断奶大鼠肝脏中线粒体和微粒体酰基辅酶A：sn-甘油3-磷酸O-酰基转移酶的活性以及丙二酰辅酶A、非酯化和酯化肉碱、甘油3-磷酸、酮体和长链酰基辅酶A酯的浓度。
Biochem J. 1981 Jul 15;198(1):75-83. doi: 10.1042/bj1980075.
5
Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.肝脏中丙二酰辅酶A对长链脂肪酸氧化调节作用的评估。该系统存在未知调节成分的证据。
Biochem J. 1980 Dec 15;192(3):959-62. doi: 10.1042/bj1920959.
6
Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.进食和饥饿大鼠线粒体中丙二酰辅酶A对生酮作用的差异抑制
Biochem J. 1980 Dec 15;192(3):955-8. doi: 10.1042/bj1920955.
7
Regulation of hepatic fatty acid oxidation and ketone body production.肝脏脂肪酸氧化及酮体生成的调节。
Annu Rev Biochem. 1980;49:395-420. doi: 10.1146/annurev.bi.49.070180.002143.
8
Acylation of carnitine and glycerophosphate in suspensions of rat liver mitochondria at varying levels of palmitate and coenzyme A.在不同棕榈酸和辅酶A水平下，大鼠肝脏线粒体悬浮液中肉碱和甘油磷酸的酰化作用。
Acta Physiol Scand. 1975 Dec;95(4):448-56. doi: 10.1111/j.1748-1716.1975.tb10073.x.
9
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.丙二酰辅酶A在分离的大鼠肝细胞中脂肪酸合成与氧化协调中的作用。
J Biol Chem. 1978 Nov 25;253(22):8294-300.
10
Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA.
Biochim Biophys Acta. 1978 Sep 28;530(3):305-13. doi: 10.1016/0005-2760(78)90150-9.