Coiro V, d'Amato L, Borciani E, Rossi G, Camellini L, Maffei M L, Pignatti D, Chiodera P
Br J Clin Pharmacol. 1984 Nov;18(5):802-5. doi: 10.1111/j.1365-2125.1984.tb02547.x.
In order to determine whether nicotine exerts its stimulant effect on serum concentrations of growth hormone (GH) by interacting with an adrenergic pathway, we evaluated the effect of cigarette smoking on the response of GH to the administration of clonidine, a specific alpha-adrenoceptor agonist. In six normal volunteers, clonidine significantly increased serum levels of GH. When subjects smoked two non-filter cigarettes, GH response to the alpha-adrenoceptor agonist was greatly enhanced. These findings suggest that in man nicotinic cholinergic and adrenergic mechanisms might interact in the stimulation of GH secretion.
为了确定尼古丁是否通过与肾上腺素能途径相互作用对生长激素（GH）的血清浓度产生刺激作用，我们评估了吸烟对GH对可乐定（一种特定的α-肾上腺素能受体激动剂）给药反应的影响。在六名正常志愿者中，可乐定显著提高了血清GH水平。当受试者吸两支无过滤嘴香烟时，GH对α-肾上腺素能受体激动剂的反应大大增强。这些发现表明，在人体中，烟碱胆碱能和肾上腺素能机制可能在刺激GH分泌中相互作用。
