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美加明可阻断尼古丁对大鼠下丘脑促性腺激素和促甲状腺激素分泌的抑制作用，以及尼古丁引起的儿茶酚胺周转率的增加。

Mecamylamine induced blockade of nicotine induced inhibition of gonadotrophin and TSH secretion and of nicotine induced increases of catecholamine turnover in the rat hypothalamus.

作者信息

Andersson K, Fuxe K, Eneroth P, Gustafsson J A, Agnati L F

出版信息

Acta Physiol Scand Suppl. 1980;479:27-9.

PMID:6932802
Abstract

Nicotine treatment of normal male rats and of ovariectomized female rats results in increases of dopamine (DA), noradrenaline (NA) and adrenaline (A) turnover in the hypothalamus, especially within the median eminence. These effects may in part mediate the inhibition of gonadotrophin and TSH secretion produced by nicotine.

摘要

对正常雄性大鼠和去卵巢雌性大鼠进行尼古丁处理，会导致下丘脑尤其是正中隆起内的多巴胺（DA）、去甲肾上腺素（NA）和肾上腺素（A）周转率增加。这些效应可能部分介导了尼古丁对促性腺激素和促甲状腺激素分泌的抑制作用。

相似文献

1
Mecamylamine induced blockade of nicotine induced inhibition of gonadotrophin and TSH secretion and of nicotine induced increases of catecholamine turnover in the rat hypothalamus.美加明可阻断尼古丁对大鼠下丘脑促性腺激素和促甲状腺激素分泌的抑制作用，以及尼古丁引起的儿茶酚胺周转率的增加。
Acta Physiol Scand Suppl. 1980;479:27-9.
2
Involvement of cholinergic nicotine-like receptors as modulators of amine turnover in various types of hypothalamic dopamine and noradrenaline nerve terminal systems and of prolactin, LH, FSH and TSH secretion in the castrated male rat.胆碱能烟碱样受体作为去势雄性大鼠各种类型下丘脑多巴胺和去甲肾上腺素神经末梢系统中胺代谢的调节剂以及催乳素、促黄体生成素、促卵泡生成素和促甲状腺激素分泌的调节剂的作用。
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3
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Acta Physiol Scand. 1981 Oct;113(2):227-31. doi: 10.1111/j.1748-1716.1981.tb06887.x.
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引用本文的文献

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Psychopharmacology (Berl). 1997 Feb;129(3):225-32. doi: 10.1007/s002130050184.
2
Neuroendocrine regulation of thyrotropin-releasing hormone (TRH) in the tuberoinfundibular system.结节漏斗系统中促甲状腺激素释放激素（TRH）的神经内分泌调节。
J Endocrinol Invest. 1993 Oct;16(9):715-53. doi: 10.1007/BF03348918.
3
Interactions of nicotine and pentobarbitone in the regulation of telencephalic and hypothalamic catecholamine levels and turnover and of adenohypophyseal hormone secretion in the normal male rat.
尼古丁与戊巴比妥对正常雄性大鼠端脑和下丘脑儿茶酚胺水平、周转率以及腺垂体激素分泌的调节作用
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):287-92. doi: 10.1007/BF00498515.
4
Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth hormone concentrations in men.吸烟中的尼古丁会增强可乐定诱导的男性血清生长激素浓度的升高。
Br J Clin Pharmacol. 1984 Nov;18(5):802-5. doi: 10.1111/j.1365-2125.1984.tb02547.x.
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Drugs. 1983 Apr;25(4):399-432. doi: 10.2165/00003495-198325040-00004.
6
Role of primary sensory neurons in the central effects of nicotine.
Psychopharmacology (Berl). 1988;94(4):468-70. doi: 10.1007/BF00212839.
7
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