Klein H E, Bender W, Mayr H, Niederschweiberer A, Schmauss M
Br J Psychiatry. 1984 Dec;145:591-9. doi: 10.1192/bjp.145.6.591.
The dexamethasone suppression test (DST) was administered shortly after admission to 102 consecutive in-patients with a Hamilton depression score greater than or equal to 16. Post-dexamethasone cortisol exceeded 6 micrograms/dl in 16 cases, and levels correlated significantly with Hamilton scores; with the AMP syndromes 'hypochondria', 'apathy' and 'catatonia'; and with the IMPS 'retarded depressive' syndrome. The criterion of suppression/non-suppression did not distinguish significantly between diagnostic categories (RDC or ICD), nor between endogenous and neurotic depression. (Newcastle scale). Both base-line and post-dexamethasone cortisol levels were reduced by prior treatment with minor tranquillisers, but not by major tranquillisers or antidepressants. DST results cannot be used as straightforward indicators of prognosis.
对102名汉密尔顿抑郁评分大于或等于16的连续住院患者入院后不久进行了地塞米松抑制试验（DST）。16例患者地塞米松后的皮质醇超过6微克/分升，其水平与汉密尔顿评分、AMP综合征的“疑病症”“冷漠”和“紧张症”以及IMPS的“迟滞性抑郁”综合征显著相关。抑制/未抑制标准在诊断类别（RDC或ICD）之间以及内源性抑郁和神经症性抑郁之间均无显著差异（纽卡斯尔量表）。基线和地塞米松后的皮质醇水平均因先前使用小剂量镇静剂治疗而降低，但大剂量镇静剂或抗抑郁药则无此效果。DST结果不能直接用作预后指标。
