19-去甲脱氧皮质酮和19-去甲孕酮对绵羊血压及代谢的影响

The blood pressure and metabolic effects of 19-nor-deoxycorticosterone and 19-nor-progesterone in sheep.

作者信息

Spence C D, Coghlan J P, Denton D A, Gomez-Sanchez C E, Mills E H, Nelson M A, Whitworth J A, Scoggins B A

出版信息

Clin Exp Hypertens A. 1984;6(9):1591-600. doi: 10.3109/10641968409044071.

DOI:10.3109/10641968409044071

Abstract

The present study examines the blood pressure and metabolic effects of 5 day infusions of 19-nor-deoxycorticosterone (19-nor-DOC) and 19- nor-progesterone (19-nor-PROG) in the intact conscious sheep. Both these steroids raise blood pressure in the rat. 19-nor-DOC (5 mg/d) produced a significant increase in mean arterial pressure (MAP) of 17 mmHg on day 5 (p less than 0.001), associated with 'mineralocorticoid' effects hypokalaemia, hypernatraemia and an initial urinary sodium retention. In contrast 19-nor-PROG (5 mg/d and 50 mg/d) had no effect on MAP and displayed no 'mineralocorticoid' activity.

摘要

本研究检测了在清醒的完整绵羊体内连续5天输注19-去甲脱氧皮质酮（19-nor-DOC）和19-去甲孕酮（19-nor-PROG）对血压和代谢的影响。这两种类固醇均可使大鼠血压升高。19-去甲脱氧皮质酮（5毫克/天）在第5天时使平均动脉压（MAP）显著升高17毫米汞柱（p<0.001），伴有“盐皮质激素”效应，即低钾血症、高钠血症和最初的尿钠潴留。相比之下，19-去甲孕酮（5毫克/天和50毫克/天）对MAP无影响，且未表现出“盐皮质激素”活性。