Coghlan J P, Butkus A, Denton D A, McDougall J G, Scoggins B A, Whitworth J A
Clin Exp Hypertens (1978). 1979;1(5):629-48. doi: 10.3109/10641967909068629.
9 alphafluorohydrocortisone (9 alphaFF) is an analogue of hydrocortisone with both 'mineralocorticoid' and 'glucocorticoid' activity. 9 alphaFF was infused at 0.2, 0.63 and 2.0 mg/day for 5 days to intact conscious trained sheep. At high dose (0.63 and 2 mg/day) 9 alphaFF raises blood pressure in sheep, (mean arterial pressure rise 32 and 29 mm Hg respectively on the fifth day), lowers plasma [K], raises plasma [Na] and produces initial urinary sodium retention. At low dose (0.2 mg/day) blood pressure is raised (+16 mm Hg on day 5) but plasma and urinary electrolytes are unaltered. 9 alphaFF had no effect on water intake or urine output at any dose. In all animals withdrawal of 9 alphaFF was associated with a natriuresis. On the basis of its affinity for 'mineralocorticoid' and 'glucocorticoid' ovine renal receptors, 9 alphaFF at low dose may raise blood pressure by mechanisms not simply related to its 'glucocorticoid' and/or 'mineralocorticoid' action.
9α-氟氢化可的松（9αFF）是氢化可的松的类似物，兼具“盐皮质激素”和“糖皮质激素”活性。以0.2、0.63和2.0毫克/天的剂量对完整、清醒且经过训练的绵羊输注9αFF，持续5天。在高剂量（0.63和2毫克/天）时，9αFF可使绵羊血压升高（第5天平均动脉压分别升高32和29毫米汞柱），降低血浆[钾]浓度，升高血浆[钠]浓度，并导致最初的尿钠潴留。在低剂量（0.2毫克/天）时，血压升高（第5天升高16毫米汞柱），但血浆和尿液电解质未发生改变。9αFF在任何剂量下对水摄入量或尿量均无影响。在所有动物中，停用9αFF均伴有利钠作用。基于其对绵羊肾脏“盐皮质激素”和“糖皮质激素”受体的亲和力，低剂量的9αFF升高血压的机制可能并非简单地与其“糖皮质激素”和/或“盐皮质激素”作用相关。
