Morozova O V, Parfenov Iu D
Eksp Onkol. 1986;8(3):31-2.
Uterine sarcomas in (CBA X C57B1)F1 mice receiving 1,2-dimethylhydrazine (DMH) developed in 20% of animals. Concomitant administration of estradiol-dipropionate (EP) in doses of 2, 10 and 30 micrograms/mouse significantly increased tumour incidence up to 46.9, 62.5, and 50%, respectively, and shortened their latency: 42.3 weeks in a group receiving DMH alone and 36.7, 38.4 and 30.5 weeks in groups receiving DMH plus 2, 10 or 30 micrograms EP, respectively.
接受1,2 - 二甲基肼（DMH）的（CBA×C57B1）F1小鼠中，20%的动物发生了子宫肉瘤。以2、10和30微克/小鼠的剂量同时给予二丙酸雌二醇（EP），显著提高了肿瘤发生率，分别高达46.9%、62.5%和50%，并缩短了潜伏期：单独接受DMH的组为42.3周，接受DMH加2、10或30微克EP的组分别为36.7周、38.4周和30.5周。
