Sirven Joseph I
Department of Neurology, Mayo Clinic in Arizona, Phoenix, Arizona 85054.
Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a022848. doi: 10.1101/cshperspect.a022848.
Epilepsy, a disorder of unprovoked seizures is a multifaceted disease affecting individuals of all ages with a particular predilection for the very young and old. In addition to seizures, many patients often report cognitive and psychiatric problems associated with both the seizures themselves and its therapy. Epilepsy has numerous etiologies both idiopathic and acquired with a wide range of therapeutic responses. Despite numerous treatments available to control repetitive seizures including medications, diets, immunotherapy, surgery, and neuromodulatory devices, a large percentage of patients continue to suffer the consequences of uncontrolled seizures, which include psychosocial stigma and death.
癫痫是一种无端发作的病症,是一种多方面的疾病,影响着所有年龄段的人,尤其在幼儿和老年人中更为常见。除了发作之外,许多患者还常报告与发作本身及其治疗相关的认知和精神问题。癫痫有多种病因,包括特发性和后天性的,治疗反应范围广泛。尽管有多种治疗方法可用于控制重复性发作,包括药物、饮食、免疫疗法、手术和神经调节装置,但仍有很大比例的患者继续遭受癫痫发作不受控制的后果,包括社会心理耻辱感和死亡。