索他洛尔与氢氯噻嗪固定复方制剂在中度肾功能不全高血压患者中的药代动力学
Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency.
作者信息
Kher A, Fillastre J P, Fourtillan J B, Lefebvre M A, Ingrand I
出版信息
Eur J Clin Pharmacol. 1984;27(3):361-2. doi: 10.1007/BF00542176.
PMID:6510465
Abstract
Decreased elimination of a combined formulation of Sotalol (160 mg) and hydrochlorothiazide (25 mg) was found in patients with moderate renal insufficiency. Very slight accumulation of sotalol and hydrochlorothiazide was observed, so it appears unnecessary to reduce the dosage in patients with a creatinine clearance of 30 ml/min or more.
摘要
在中度肾功能不全患者中发现索他洛尔（160毫克）与氢氯噻嗪（25毫克）联合制剂的清除率降低。观察到索他洛尔和氢氯噻嗪有非常轻微的蓄积，因此对于肌酐清除率为30毫升/分钟或更高的患者，似乎没有必要降低剂量。
Zotero 插件