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索他洛尔与氢氯噻嗪固定复方制剂在中度肾功能不全高血压患者中的药代动力学

Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency.

作者信息

Kher A, Fillastre J P, Fourtillan J B, Lefebvre M A, Ingrand I

出版信息

Eur J Clin Pharmacol. 1984;27(3):361-2. doi: 10.1007/BF00542176.

DOI:10.1007/BF00542176
PMID:6510465
Abstract

Decreased elimination of a combined formulation of Sotalol (160 mg) and hydrochlorothiazide (25 mg) was found in patients with moderate renal insufficiency. Very slight accumulation of sotalol and hydrochlorothiazide was observed, so it appears unnecessary to reduce the dosage in patients with a creatinine clearance of 30 ml/min or more.

摘要

在中度肾功能不全患者中发现索他洛尔（160毫克）与氢氯噻嗪（25毫克）联合制剂的清除率降低。观察到索他洛尔和氢氯噻嗪有非常轻微的蓄积，因此对于肌酐清除率为30毫升/分钟或更高的患者，似乎没有必要降低剂量。

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Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency.索他洛尔与氢氯噻嗪固定复方制剂在中度肾功能不全高血压患者中的药代动力学
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引用本文的文献

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本文引用的文献

1
C14-labeled hydrochlorothiazide in human beings.人体中的碳-14标记氢氯噻嗪
Arch Intern Med. 1961 May;107:736-42. doi: 10.1001/archinte.1961.03620050102011.
2
Fluorometric high-performance liquid chromatographic determination of sotalol in biological fluids.
J Pharm Sci. 1980 Oct;69(10):1216-7. doi: 10.1002/jps.2600691026.
3
Human pharmacokinetics of sotalol.索他洛尔的人体药代动力学。
Acta Pharmacol Toxicol (Copenh). 1976 Jul;39(1):118-28. doi: 10.1111/j.1600-0773.1976.tb03162.x.
4
Comparative bioavailability and pharmacokinetics of sotalol administered alone and in combination with hydrochlorothiazide.
J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 2):557-64. doi: 10.1002/j.1552-4604.1979.tb02522.x.
5
Binding of diuretics to human serum albumin and to human serum from healthy adults and patients with renal failure.利尿剂与健康成年人及肾衰竭患者的人血清白蛋白和人血清的结合。
Chem Pharm Bull (Tokyo). 1979 Jan;27(1):101-8. doi: 10.1248/cpb.27.101.