联合免疫刺激（嗜丙酸杆菌KP 40）和抗凝（肝素）可预防小鼠肺部和肝脏的转移性定植。
Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice.
作者信息
Beuth J, Ko H L, Uhlenbruck G, Pulverer G
出版信息
J Cancer Res Clin Oncol. 1987;113(4):359-62. doi: 10.1007/BF00397719.
Abstract
The antineoplastic activity of Propionibacterium avidum KP-40 and its enhancement by anticoagulation with heparin was studied. In Balb/c mice syngeneic sarcoma L-1 exclusively caused tumor colonization of the lungs. After neuraminidase treatment the organotropism of this tumor was changed, with tumor nodules developing in lung and liver. After single systemic application of Propionibacterium avidum KP-40 the number of lung and liver colonies decreased evidently. Combination of this immunomodulating therapy with temporary anticoagulation resulted in further reduction of tumor colonies in lung and liver.
摘要
研究了嗜丙酸杆菌KP-40的抗肿瘤活性及其通过肝素抗凝作用的增强效果。在同基因Balb/c小鼠中，肉瘤L-1仅在肺部形成肿瘤定植。经神经氨酸酶处理后，该肿瘤的器官嗜性发生改变，在肺和肝脏中出现肿瘤结节。单次全身应用嗜丙酸杆菌KP-40后，肺和肝脏中的菌落数量明显减少。这种免疫调节疗法与临时抗凝相结合，导致肺和肝脏中肿瘤菌落的进一步减少。
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