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联合免疫刺激（嗜丙酸杆菌KP 40）和抗凝（肝素）可预防小鼠肺部和肝脏的转移性定植。

Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice.

作者信息

Beuth J, Ko H L, Uhlenbruck G, Pulverer G

出版信息

J Cancer Res Clin Oncol. 1987;113(4):359-62. doi: 10.1007/BF00397719.

DOI:10.1007/BF00397719
PMID:3597521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12248343/
Abstract

The antineoplastic activity of Propionibacterium avidum KP-40 and its enhancement by anticoagulation with heparin was studied. In Balb/c mice syngeneic sarcoma L-1 exclusively caused tumor colonization of the lungs. After neuraminidase treatment the organotropism of this tumor was changed, with tumor nodules developing in lung and liver. After single systemic application of Propionibacterium avidum KP-40 the number of lung and liver colonies decreased evidently. Combination of this immunomodulating therapy with temporary anticoagulation resulted in further reduction of tumor colonies in lung and liver.

摘要

研究了嗜丙酸杆菌KP-40的抗肿瘤活性及其通过肝素抗凝作用的增强效果。在同基因Balb/c小鼠中，肉瘤L-1仅在肺部形成肿瘤定植。经神经氨酸酶处理后，该肿瘤的器官嗜性发生改变，在肺和肝脏中出现肿瘤结节。单次全身应用嗜丙酸杆菌KP-40后，肺和肝脏中的菌落数量明显减少。这种免疫调节疗法与临时抗凝相结合，导致肺和肝脏中肿瘤菌落的进一步减少。

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1
Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice.联合免疫刺激（嗜丙酸杆菌KP 40）和抗凝（肝素）可预防小鼠肺部和肝脏的转移性定植。
J Cancer Res Clin Oncol. 1987;113(4):359-62. doi: 10.1007/BF00397719.
2
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3
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4
Combined immunomodulation (Propionibacterium avidum KP-40) and lectin blocking (D-galactose) prevents liver tumor colonization in BALB/c-mice.
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Immunostimulation by propionibacteria--effects on immune status and antineoplastic treatment.丙酸杆菌引起的免疫刺激——对免疫状态和抗肿瘤治疗的影响
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Immunostimulating cell surface substance from Staphylococcus epidermidis strain ATCC-31432 prevents metastatic lung colonization in Balb/c-mice.来自表皮葡萄球菌菌株ATCC - 31432的免疫刺激细胞表面物质可防止Balb/c小鼠发生转移性肺定植。
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本文引用的文献

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The correlation of susceptibility of different Propionibacterium strains to macrophage killing and antitumor activity.不同丙酸杆菌菌株对巨噬细胞杀伤的敏感性与抗肿瘤活性之间的相关性。
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The in vivo cytostatic effect induced by Propionibacterium granulosum on murine tumor cells.颗粒丙酸杆菌对小鼠肿瘤细胞诱导的体内细胞生长抑制作用。
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Effect of three strains of propionibacteria (P. granulosum, P. avidum, P. acnes) and cell-wall preparations on lymphocytes and macrophages.三种丙酸杆菌菌株（颗粒丙酸杆菌、嗜丙酸丙酸杆菌、痤疮丙酸杆菌）及细胞壁制剂对淋巴细胞和巨噬细胞的影响。
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4
Comparative study on the immunostimulatory potency of different Propionibacterium strains.不同丙酸杆菌菌株免疫刺激效力的比较研究。
Med Microbiol Immunol. 1981;170(1):1-9. doi: 10.1007/BF02123791.
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The Thomsen-Friedenreich (TF) receptor: an old history with new mystery.汤姆森-弗里德赖希（TF）受体：一段有着新谜团的古老历史。
Immunol Commun. 1981;10(3):251-64. doi: 10.3109/08820138109093459.
6
Relationship between cellular procoagulant activity and metastatic capacity of B16 mouse melanoma variants.B16小鼠黑色素瘤变体的细胞促凝活性与转移能力之间的关系
Cancer Res. 1983 Feb;43(2):536-40.
7
Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease.巨噬细胞介导的恶性肿瘤细胞破坏及转移性疾病治疗的新策略。
Springer Semin Immunopathol. 1982;5(2):161-74. doi: 10.1007/BF00199794.
8
Stimulatory effect of Propionibacterium granulosum KP-45, glucan and pyran copolymer on the activity of natural killer (NK) cells in murine lungs.颗粒丙酸杆菌KP-45、葡聚糖和吡喃共聚物对小鼠肺中自然杀伤（NK）细胞活性的刺激作用。
Immunobiology. 1984 Oct;167(4):328-37. doi: 10.1016/S0171-2985(84)80004-2.
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Activation of blood coagulation in cancer: Trousseau's syndrome revisited.癌症中血液凝固的激活：重新审视特鲁索综合征。
Blood. 1983 Jul;62(1):14-31.
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Inhibition of the arrest of hematogenously disseminated tumor cells.抑制血行播散肿瘤细胞的滞留。
Cancer Metastasis Rev. 1983;2(3):223-37. doi: 10.1007/BF00048479.