实验性恶性肿瘤中的血清铜和铜蓝蛋白活性

Serum copper and caeruloplasmin activity in experimental malignancies.

作者信息

Chakravarty P K, Ghosh A, Chowdhury J R

出版信息

J Comp Pathol. 1984 Oct;94(4):603-6. doi: 10.1016/0021-9975(84)90064-1.

PMID:6512031

Abstract

Serum copper content and caeruloplasmin activity were measured in 595 Strain A male mice. The mice carried either benzo(a)pyrene induced fibrosarcoma, transplanted sarcoma-180, Dalton's lymphoma, or Ehrlich carcinoma. The serum copper concentration was raised in all the tumours when compared with normal controls. The observed fall in activity of caeruloplasmin during malignancy may be related to defective iron mobilization.

摘要

对595只A品系雄性小鼠的血清铜含量和铜蓝蛋白活性进行了测定。这些小鼠分别携带苯并(a)芘诱导的纤维肉瘤、移植性肉瘤-180、道尔顿淋巴瘤或艾氏癌。与正常对照组相比，所有肿瘤小鼠的血清铜浓度均升高。在恶性肿瘤期间观察到的铜蓝蛋白活性下降可能与铁动员缺陷有关。