Chakravarty P K, Ghosh A, Chowdhury J R
Department of Tumour Biology, Chittaranjan National Cancer Research Centre, Calcutta, India.
Cancer Lett. 1994 Sep 15;84(2):177-82. doi: 10.1016/0304-3835(94)90373-5.
Copper and zinc concentrations in erythrocytes, plasma and whole blood were determined in mice bearing spontaneous-, transplanted- and benezo[a]pyrene-induced-tumour. The transplanted tumours studied were Sarcoma 180, Ehrlich carcinoma, and Dalton's lymphoma. Copper concentration in the malignant-tumour-bearing mice showed significant increases in erythrocytes and plasma, when compared with their normal controls. However, the zinc concentrations, although depressed in the different constituents of blood, were not significant enough to warrant any attention. Utilization of erythrocyte copper level as an additional marker of cancer activity is discussed.
对患有自发性肿瘤、移植性肿瘤和苯并[a]芘诱导性肿瘤的小鼠的红细胞、血浆和全血中的铜和锌浓度进行了测定。所研究的移植性肿瘤为肉瘤180、艾氏癌和道尔顿淋巴瘤。与正常对照组相比，患恶性肿瘤小鼠的红细胞和血浆中的铜浓度显著升高。然而，锌浓度虽然在血液的不同成分中有所降低，但降低程度不足以引起重视。本文还讨论了将红细胞铜水平用作癌症活性附加标志物的用途。
