Starink T M, Hausman R
J Cutan Pathol. 1984 Oct;11(5):331-7. doi: 10.1111/j.1600-0560.1984.tb00388.x.
A study of 11 facial lesions from 7 patients with Cowden's disease indicated that most belong to a spectrum of related follicular malformations. The most distinctive lesions included multiple facial trichilemmomas, which were frequently cylindrical, resembling a blown-up hair follicle, but could be lobular. Four of the 5 trichilemmomal lesions were from the centrofacial area. Three periauricular lesions showed the pattern of tumor of follicular infundibulum without trichilemmonal features. Two lesions were epidermal without a follicular component and resembled digitate warts. No evidence of virus infection was found using an antiserum to papilloma virus.
一项针对7例考登病患者的11处面部病变的研究表明，大多数病变属于一系列相关的毛囊畸形。最具特征性的病变包括多发性面部毛发上皮瘤，其通常呈圆柱形，类似膨大的毛囊，但也可能呈小叶状。5处毛发上皮瘤性病变中有4处来自面部中央区域。3处耳周病变表现为毛囊漏斗部肿瘤的形态，无毛发上皮瘤特征。2处病变为表皮性，无毛囊成分，类似指状疣。使用乳头瘤病毒抗血清未发现病毒感染的证据。
