Patchen M L, DiLuzio N R, Jacques P, MacVittie T J
J Biol Response Mod. 1984 Dec;3(6):627-33.
Six soluble polyglycans (glucan-C, glucan-F, glucan-S, krestin, lentinan, and schizophyllan), two soluble polymannans (mannan-A and mannan-R), and one soluble polyfructan (levan) were assayed for their ability to enhance hemopoietic recovery in C3H/HeN mice when administered either 1 h before or 1 h after a 6.5-Gy dose of cobalt-60 radiation. Hemopoietic recovery was measured by the endogenous spleen colony assay and was compared with recovery in both radiation control mice and irradiated mice treated with glucan-P (a particulate polyglycan previously shown to enhance recovery from radiation-induced hemopoietic injury). Compared with radiation controls, when administered before irradiation, mannan-A, glucan-F, and glucan-S enhanced endogenous colony formation 4.2-5.1-fold (equivalent to glucan-P), and levan and schizophyllan approximately 2.7-fold. Lentinan, krestin, mannan-R, and glucan-C did not enhance hemopoietic recovery above radiation controls under these conditions. When polyglycan administration was delayed until after irradiation, endogenous colony formation was enhanced 3.0-3.9-fold by mannan-A, schizophyllan, glucan-S, krestin, and glucan-F (at least comparable with glucan-P) but not at all by mannan-R, levan, lentinan, or glucan-C.
检测了六种可溶性多糖（葡聚糖-C、葡聚糖-F、葡聚糖-S、云芝多糖、香菇多糖和裂褶多糖）、两种可溶性多聚甘露糖（甘露聚糖-A和甘露聚糖-R）以及一种可溶性多聚果糖（果聚糖），在给C3H/HeN小鼠6.5 Gy剂量的钴-60辐射前1小时或辐射后1小时给药时，增强造血恢复的能力。通过内源性脾集落试验测量造血恢复情况，并与辐射对照小鼠和用葡聚糖-P（一种先前已证明能增强辐射诱导的造血损伤恢复的颗粒状多糖）治疗的辐射小鼠的恢复情况进行比较。与辐射对照组相比，在照射前给药时，甘露聚糖-A、葡聚糖-F和葡聚糖-S使内源性集落形成增加4.2至5.1倍（相当于葡聚糖-P），果聚糖和裂褶多糖增加约2.7倍。在这些条件下，香菇多糖、云芝多糖、甘露聚糖-R和葡聚糖-C没有使造血恢复超过辐射对照组。当多糖给药延迟至照射后时，甘露聚糖-A、裂褶多糖、葡聚糖-S、云芝多糖和葡聚糖-F使内源性集落形成增加3.0至3.9倍（至少与葡聚糖-P相当），但甘露聚糖-R、果聚糖、香菇多糖或葡聚糖-C则完全没有作用。
