Boer G J, van der Woude T P, Kruisbrink J, van Heerikhuize J
J Neurosci Methods. 1984 Sep;11(4):281-9. doi: 10.1016/0165-0270(84)90090-6.
A recently developed small controlled-delivery peptide device has now been further miniaturized (3.5 mm3 rod) and its action has been tested in vitro and in vivo using vasopressin (VP) as experimental substance. In vitro immersion showed a constant and lasting release of VP for weeks, as had been described for larger devices. By introducing the mini-device into the lateral ventricle of rat brain and by sampling CSF via a permanent cannula in the cisterna magna, a steadily enhanced level of VP could be attained for CSF. These increased levels persisted for one week, but most likely continue for longer periods.
一种最近研发的小型控释肽装置现已进一步小型化（3.5立方毫米棒状），并以加压素（VP）作为实验物质在体外和体内对其作用进行了测试。体外浸泡显示，与较大装置的情况一样，VP能持续稳定释放数周。通过将微型装置植入大鼠脑侧脑室，并通过枕大池中的永久性套管采集脑脊液，脑脊液中的VP水平可稳步提高。这些升高的水平持续了一周，但很可能会持续更长时间。
