[Cytophotometric study of the change in DNA content in the nuclei of human blood lymphocytes in systemic lupus erythematosus].

During systemic lupus erythematosus, a correlation between the nuclear DNA contents in lymphocytes and their tendency to proliferate, on the one hand, and the activity of disease, on the other hand, has been revealed. At the high activity and acute run of disease, a negative tendency of lymphocyte proliferation and negative figures of the index of proliferation prevailed, the findings reflecting the extent of diminution of the lymphocyte DNA amounts. With a decline in the activity of disease and its transition to a phase of remission, a positive proliferative tendency starts to predominate in lymphocytes.