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杀菌剂五氯硝基苯和六氯苯衍生物在哺乳动物体内的生物转化

Biotransformation of derivatives of the fungicides pentachloronitrobenzene and hexachlorobenzene in mammals.

作者信息

Renner G, Nguyen P T

出版信息

Xenobiotica. 1984 Sep;14(9):693-704. doi: 10.3109/00498258409151467.

DOI:10.3109/00498258409151467
PMID:6516442
Abstract

Biotransformation of N-acetyl-S-(2,3,5,6-tetrachlorophenyl)cysteine and N-acetyl-S-(pentachlorophenyl)cysteine-S-oxide, of the metabolites of both PCNB and HCB, namely N-acetyl-S-(pentachlorophenyl)cysteine, pentachlorothiophenol, pentachlorothioanisole, 4-methylthio-tetrachlorothiophenol and tetrachloro-1,4-bis(methylthio)benzene, and of the PCNB metabolites, S,S'-(tetrachloro-p-phenylene)dicysteine, and the isomeric tetrachlorothiophenols, has been studied in rabbits, rats and mice, as well as in vitro. Biotransformation products such as thiophenols, thioanisoles, chlorinated benzenes, phenols and anisoles have been identified by g.l.c.

摘要

对五氯硝基苯(PCNB)和六氯苯(HCB)的代谢产物N-乙酰-S-(2,3,5,6-四氯苯基)半胱氨酸和N-乙酰-S-(五氯苯基)半胱氨酸-S-氧化物、PCNB的代谢产物N-乙酰-S-(五氯苯基)半胱氨酸、五氯苯硫酚、五氯苯甲醚、4-甲硫基-四氯苯硫酚和四氯-1,4-双(甲硫基)苯,以及PCNB代谢产物S,S'-(四氯-对亚苯基)二半胱氨酸和异构四氯苯硫酚在兔、大鼠和小鼠体内以及体外的生物转化进行了研究。已通过气相色谱法鉴定出生物转化产物,如苯硫酚、苯甲醚、氯化苯、苯酚和苯甲醚。

相似文献

1
Biotransformation of derivatives of the fungicides pentachloronitrobenzene and hexachlorobenzene in mammals.杀菌剂五氯硝基苯和六氯苯衍生物在哺乳动物体内的生物转化
Xenobiotica. 1984 Sep;14(9):693-704. doi: 10.3109/00498258409151467.
2
Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene.杀菌剂六氯苯和五氯硝基苯的生物转化
Xenobiotica. 1981 Jul;11(7):435-46. doi: 10.3109/00498258109045854.
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Mechanisms of the reductive denitration of pentachloronitrobenzene (PCNB) and the reductive dechlorination of hexachlorobenzene (HCB).五氯硝基苯(PCNB)的还原脱硝和六氯苯(HCB)的还原脱氯机制。
Xenobiotica. 1984 Sep;14(9):705-10. doi: 10.3109/00498258409151468.
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Metabolic studies on pentachloronitrobenzene (PCNB) in rats.大鼠体内五氯硝基苯(PCNB)的代谢研究。
Xenobiotica. 1980 Jul-Aug;10(7-8):537-50. doi: 10.3109/00498258009033788.
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Studies on sex differences in excretion of sulphur derivatives of hexachlorobenzene and pentachloronitrobenzene by rats.
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The mercapturic acid biotransformation pathway of hexachlorobenzene is not involved in the induction of splenomegaly, or skin and lung lesions in the Brown Norway rat.
Arch Toxicol. 2000 Dec;74(10):609-17. doi: 10.1007/s002040000166.
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Comparative metabolism of hexachlorobenzene and pentachloronitrobenzene in plants, rats, and rhesus monkeys.六氯苯和五氯硝基苯在植物、大鼠及恒河猴体内的代谢比较
Ecotoxicol Environ Saf. 1978 Dec;2(3-4):437-45. doi: 10.1016/s0147-6513(78)80017-7.
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Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxy-lyase.筛选六氯苯代谢物降低大鼠肝脏卟啉原羧化酶活性的能力。
Res Commun Chem Pathol Pharmacol. 1986 Mar;51(3):325-36.
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Formation of pentachlorothioanisole from N-acetyl-S-(pentachlorophenyl) cysteine in blood and liver of rats "in vivo".
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Tissue residues from feeding pentachloronitrobenzene (quintozene) to White Leghorn chickens.
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Effects of pentachlorophenol and some of its known and possible metabolites on fungi.五氯苯酚及其一些已知和可能的代谢产物对真菌的影响。
Appl Environ Microbiol. 1986 Jun;51(6):1370-2. doi: 10.1128/aem.51.6.1370-1372.1986.