筛选具有抗疱疹活性的新化合物。

Screening for new compounds with antiherpes activity.

作者信息

Alarcón B, Lacal J C, Fernández-Sousa J M, Carrasco L

出版信息

Antiviral Res. 1984 Oct;4(5):231-44. doi: 10.1016/0166-3542(84)90029-9.

Abstract

A number of compounds have been tested for antiherpes activity. Actinobolin, amicetin, carrageenan, laspartomycin, megalomycin C, pleuromutilin, suramin and tetracenomycin C showed significant protection of HeLa cell monolayers infected with herpes simplex virus type 1. The action of these new antiherpes compounds was compared with those antiherpes agents that have been described previously. Actinobolin, amicetin and tetracenomycin C were also active against viruses other than herpes simplex.

摘要

已经对多种化合物进行了抗疱疹活性测试。放线菌素、友菌素、角叉菜胶、天冬霉素、巨大霉素C、截短侧耳素、苏拉明和四环素霉素C对感染1型单纯疱疹病毒的HeLa细胞单层显示出显著的保护作用。将这些新型抗疱疹化合物的作用与先前描述的抗疱疹药物进行了比较。放线菌素、友菌素和四环素霉素C对除单纯疱疹病毒以外的其他病毒也有活性。