对非洲猪瘟病毒有效的新型制剂。
New agents active against African swine fever virus.
作者信息
Sola A, Rodríguez S, Gil-Fernández C, Alarcón B, González M E, Carrasco L
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):284-8. doi: 10.1128/AAC.29.2.284.
Abstract
Actinobolin, atropine, carrageenan, megalomycin C, suramin, and tetracenomycin C were tested for their activity against African swine fever virus replication. Both viral inhibitory potency and cytotoxicity were investigated. Megalomycin C, suramin, atropine, and carrageenan exhibited significant activity. Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the formation of infectious virus by 50%. Suramin was the next most active agent in this respect, but because of its lower cytotoxicity, it had the most favorable therapeutic index.
摘要
对放线菌素、阿托品、角叉菜胶、巨大霉素C、苏拉明和四环素霉素C进行了抗非洲猪瘟病毒复制活性测试。同时研究了它们的病毒抑制效力和细胞毒性。巨大霉素C、苏拉明、阿托品和角叉菜胶表现出显著活性。就阻断50%感染性病毒形成的化合物浓度而言，巨大霉素C是这四种药物中活性最高的。在这方面，苏拉明是第二活性最高的药物，但由于其较低的细胞毒性，它具有最有利的治疗指数。
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