Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
Physiol Rep. 2024 Sep;12(17):e70041. doi: 10.14814/phy2.70041.
Experiments should always be based on control values. This assumption fully applies to cardiovascular parameters, such as heart rate (HR) and blood pressure (BP), which are highly sensitive to various external and internal stimuli and can already be significantly altered when an experiment begins. Therefore, it is necessary to determine which values are defined as a starting point (i.e., control and baseline) or compare them with valid reference values if the goal is to evaluate the changes after experimental intervention. A generally accepted principle is a reciprocal relationship between BP and HR, in which one parameter affects the other and vice versa. BP can be measured using two methods-noninvasively (tail-cuff) and invasively (telemetry, direct measurements of BP after introducing the sensor directly into the artery), and HR directly or by extrapolation from BP recordings. This study does not aim to evaluate the results of individual studies, but to review whether there are differences in control (baseline) BP values in normotensive and hypertensive male rats using invasive versus noninvasive methods, and to investigate whether there is a causal relationship between BP and HR in in vivo experiments with male rats.
实验应始终基于对照值。这一假设完全适用于心血管参数，如心率（HR）和血压（BP），它们对外界和内部刺激非常敏感，甚至在实验开始时就可能发生显著变化。因此，如果实验目的是评估实验干预后的变化，则有必要确定哪些值定义为起点（即对照和基线），或者将其与有效参考值进行比较。一个被普遍接受的原则是血压（BP）和心率（HR）之间的相互关系，其中一个参数会影响另一个参数，反之亦然。血压（BP）可以通过两种方法进行测量——非侵入性（尾套）和侵入性（遥测，在将传感器直接引入动脉后直接测量血压），心率（HR）可以直接测量，也可以通过从血压（BP）记录中推断出来。本研究的目的不是评估个别研究的结果，而是评估使用侵入性和非侵入性方法测量正常血压和高血压雄性大鼠的对照（基线）血压值是否存在差异，并研究雄性大鼠体内实验中血压（BP）和心率（HR）之间是否存在因果关系。
