甲状腺素结合球蛋白浓度：直接测定法的价值
Concentration of thyroxine-binding globulin: value of direct assay.
作者信息
Burr W A, Ramsden D B, Evans S E, Hogan T, Hoffenberg R
出版信息
Br Med J. 1977 Feb 19;1(6059):485-8. doi: 10.1136/bmj.1.6059.485.
Abstract
The concentration of thyroxine-binding globulin (TBG) in the serum can now be measured by direct assays that are simple and inexpensive. Comparison of a direct measurement of TBG concentration with a widely used indirect method (Thyopac-3) showed that the indirect method was inaccurate when TBG concentrations were high. This will result in an increase in the derived free thyroxine index (FTI), so that euthyroid patients with a raised TBG concentration may be at risk of being labelled thyrotoxic. Correction of serum total thyroxine (T4) concentration according to the actual TBG concentration (T4:TBG ratio) provided a better correlation with thyroid state than FTI.
摘要
现在可以通过简单且成本低廉的直接检测法来测定血清中甲状腺素结合球蛋白（TBG）的浓度。将TBG浓度的直接测定结果与一种广泛使用的间接方法（Thyopac-3）进行比较，结果显示当TBG浓度较高时，间接方法不准确。这会导致计算得出的游离甲状腺素指数（FTI）升高，从而使TBG浓度升高的甲状腺功能正常患者可能有被误诊为甲状腺毒症的风险。根据实际TBG浓度（T4:TBG比值）对血清总甲状腺素（T4）浓度进行校正，与甲状腺状态的相关性比FTI更好。
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本文引用的文献
1
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J Clin Endocrinol Metab. 1965 Jan;25:39-45. doi: 10.1210/jcem-25-1-39.
2
Reverse-flow zone electrophoresis; a method for determining the thyroxine-binding capacity of serum protein.反流区带电泳法；一种测定血清蛋白甲状腺素结合能力的方法。
Arch Biochem Biophys. 1956 Aug;63(2):461-9. doi: 10.1016/0003-9861(56)90062-5.
3
Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.在含有抗体的琼脂糖凝胶中通过电泳对蛋白质进行定量估计。
Anal Biochem. 1966 Apr;15(1):45-52. doi: 10.1016/0003-2697(66)90246-6.
4
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6
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