Daskalopoulos D A, Shepherd J T, Walgenbach S C
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1417-21. doi: 10.1152/jappl.1984.57.5.1417.
To examine the role of cardiopulmonary receptors in arterial blood pressure regulation during and after exercise, conscious dogs with chronic sinoaortic denervation were subjected to 12 min of light exercise and 12 min of exercise that increased in severity every 3 min. Hemodynamic measurements were made before and after interruption of cardiopulmonary afferents by bilateral cervical vagotomy. During both exercise protocols, after an initial transient decrease, the arterial blood pressure remained close to resting values before and after vagotomy. On cessation of the graded exercise, the arterial blood pressure did not change before, but a rapid and sustained increase in pressure occurred after vagotomy. At the time of this increase the cardiac output and heart rate were returning rapidly to the resting level. The study demonstrates that in the chronic absence of arterial baroreflexes, vagal afferents prevent a rise in arterial blood pressure after vigorous exercise presumably by the action of cardiopulmonary receptors causing a rapid dilatation of systemic resistance vessels.
为了研究心肺感受器在运动期间及运动后动脉血压调节中的作用，对慢性去窦弓神经的清醒犬进行12分钟的轻度运动以及每3分钟强度增加一次的12分钟运动。在通过双侧颈迷走神经切断术中断心肺传入神经之前和之后进行血流动力学测量。在两种运动方案中，在最初短暂下降之后，迷走神经切断术前和术后动脉血压均保持接近静息值。在分级运动停止时，迷走神经切断术前动脉血压没有变化，但迷走神经切断术后血压迅速且持续升高。在血压升高时，心输出量和心率迅速恢复到静息水平。该研究表明，在长期缺乏动脉压力反射的情况下，迷走神经传入神经可能通过心肺感受器的作用导致全身阻力血管迅速扩张，从而防止剧烈运动后动脉血压升高。
