Kuwayama N, Sugita K, Sonobe M, Takahashi S
No Shinkei Geka. 1984 Dec;12(13):1535-8.
A rare case of spontaneous bilateral extradural hematomas probably due to hypofibrinogenemia is reported. On April 17, 1983, a 21-year-old woman was referred to our hospital because of her comatose state. She has complained of her longer duration of menstrual bleeding lasting 10 days to 2 weeks, but has had no history of hemorrhagic diseases. At the last night, she complained of headache and vomited several times, after drinking some beer but she went to bed without therapy. We cannot see a history of her head injury several days before admission. On admission, she was comatose with bilateral dilated pupils and flexed her upper extremities against painful stimuli. There was a tendency for subcutaneous hematomas to form immediately in places where the stimuli were applied. Skull fracture was not found on craniogram and CT scan showed bilateral extradural hematomas (60 ml on the right side and 130 ml on the left side). Laboratory data showed leukocytosis (14800), longer prothrombin time (15.2 seconds with a control of 11.9 seconds), markedly elongated activated partial thromboplastin time (90 seconds with a control of 15-45 seconds) and decreased fibrinogen concentration (114 mg/dl with a control of 200-400 mg/dl). At the bilateral decompressive craniectomies with infusion of 5 gram of fibrinogen and 300 ml of fresh blood, we found neither scalp hemorrhage nor skull fracture and after removal of coagulated hematomas no dural anomaly was found. After operation she improved gradually and laboratory re-examination was normal including bone marrow puncture. Now, 5 months after operation she is clear with slight tetraparesis on her rehabilitating course.(ABSTRACT TRUNCATED AT 250 WORDS)
本文报道了一例可能因纤维蛋白原血症导致的罕见自发性双侧硬膜外血肿病例。1983年4月17日,一名21岁女性因昏迷状态被转诊至我院。她主诉经期出血时间延长,持续10天至2周,但无出血性疾病史。昨晚,她在喝了一些啤酒后出现头痛并呕吐数次,但未治疗便上床睡觉。入院前数天未见头部受伤史。入院时,她昏迷,双侧瞳孔散大,对疼痛刺激时上肢屈曲。在施加刺激的部位立即有形成皮下血肿的倾向。颅骨X线片未发现颅骨骨折,CT扫描显示双侧硬膜外血肿(右侧60毫升,左侧130毫升)。实验室检查显示白细胞增多(14800)、凝血酶原时间延长(15.2秒,对照为11.9秒)、活化部分凝血活酶时间明显延长(90秒,对照为15 - 45秒)以及纤维蛋白原浓度降低(114毫克/分升,对照为200 - 400毫克/分升)。在双侧减压颅骨切除术并输注5克纤维蛋白原和300毫升新鲜血液时,未发现头皮出血和颅骨骨折,清除凝血块后也未发现硬脑膜异常。术后她逐渐好转,包括骨髓穿刺在内的实验室复查结果正常。现在,术后5个月,她神志清醒,在康复过程中稍有四肢轻瘫。(摘要截断于250字)