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四种抗真菌药物在皮肤滞留时间试验中的抗真菌活性。

Antifungal activity of four antifungal drugs in the cutaneous retention time test.

作者信息

Polak A

出版信息

Sabouraudia. 1984;22(6):501-3. doi: 10.1080/00362178485380781.

DOI:10.1080/00362178485380781
PMID:6523308
Abstract

The protective prophylactic activity of tolciclate, bifonazole, oxiconazole and Ro 14-4767/002 which may reflect their presence in the horny layer was examined in guinea pigs. Guinea pigs were topically treated with the drug and infected on the application site with Trichophyton mentagrophytes spores at various time intervals. Tolciclate showed the highest prophylactic activity, followed by oxiconazole, Ro 14-4767/002 and bifonazole.

摘要

在豚鼠身上检测了托萘酯、联苯苄唑、奥昔康唑和Ro 14-4767/002的预防性保护活性，这可能反映了它们在角质层中的存在情况。豚鼠局部用药物治疗，并在不同时间间隔在用药部位接种须癣毛癣菌孢子。托萘酯显示出最高的预防活性，其次是奥昔康唑、Ro 14-4767/002和联苯苄唑。

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Antimicrob Agents Chemother. 1988 Oct;32(10):1586-7. doi: 10.1128/AAC.32.10.1586.
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