Atilola M A, Lumsden J H, Hulland T J, Pennock P W
Am J Vet Res. 1984 Dec;45(12):2651-7.
The effect of analytical grade metrizamide (AM) injected into the canine stifle, for purposes of arthrography, was studied in 12 adult dogs using saline solution as the control solution injected into the contralateral joints. The AM was used at a concentration of 280 mg of iodine/ml and was administered at the dose of 0.3 ml/cm thickness of the stifle joint. For each joint, arthrocentesis was done before and 7 days after injection of either the contrast medium or saline solution. Physical, biochemical, and cytologic examinations were done on the synovial fluid while the synovial membranes and femoral articular cartilages were sectioned, stained, and examined for histopathologic changes. At the 95% confidence level, significant differences in the total and differential mononuclear cell counts were not seen between the AM- and saline solution-injected joints. However, some subtle changes in the synovial membranes were observed. Intra-articular injection of AM or saline solution initiated a mild inflammatory response, the AM causing slightly more response than the saline solution.
为进行关节造影，将分析纯甲泛葡胺（AM）注入犬膝关节，以生理盐水作为对照溶液注入对侧关节，对12只成年犬进行了研究。AM的使用浓度为280毫克碘/毫升，给药剂量为膝关节厚度每厘米0.3毫升。对于每个关节，在注射造影剂或生理盐水之前及之后7天进行关节穿刺。对滑液进行物理、生化和细胞学检查，同时对滑膜和股骨关节软骨进行切片、染色，并检查组织病理学变化。在95%置信水平下，注入AM的关节和注入生理盐水的关节之间，单核细胞总数和分类计数未见显著差异。然而，观察到滑膜有一些细微变化。关节内注射AM或生理盐水引发了轻度炎症反应，AM引起的反应略多于生理盐水。
