Iakovlev V P, Bobrov V I, Rudzit E A, Ermole nko V M, Zaslavskaia R M
Antibiotiki. 1981 Mar;26(3):136-9.
Examinations of patients suffering from chronic nephritis with the nephrotoxic syndrome and amyloidosis of the kidneys with unchanged glomerular filtration showed that the rate of sulfalen excretion in the patients with the kidney diseases was higher than that in the persons of the control group. The sulfalen elimination rate and the plasmatic clearance in such patients were higher. The higher rate of sulfalen elimination was due to increased excretion of the unchanged drug with urine.
对患有慢性肾炎伴肾毒性综合征以及肾小球滤过功能未改变的肾淀粉样变性的患者进行检查发现，患有肾脏疾病的患者中磺胺异噁唑的排泄率高于对照组人员。此类患者中磺胺异噁唑的消除率和血浆清除率较高。磺胺异噁唑消除率较高是由于尿液中未改变的药物排泄增加。
