Sinitsyn M A, Zhukovskaia S A, Murav'eva S A
Antibiotiki. 1984 Dec;29(12):897-901.
A model for determination of the admixture concentration in the secondary mother solution was developed. The concentration was determined depending on the solvent volume used for repulping the precipitate and on the impurity level of the initial antibiotic paste. When the values of X1 and X2 are known it is possible to estimate the amount of the admixtures remaining in the paste layer after separation of the secondary mother solution with regard to the volume of the latter in the precipitate pores. Optimization of paste repulping should be considered in combination with displacement washing and the apparatus used for separation of the phases, as well as the requirements for the purity level of the finished product.
建立了一种用于测定二次母液中杂质浓度的模型。该浓度取决于用于再浆化沉淀物的溶剂量以及初始抗生素糊剂的杂质水平。当已知X1和X2的值时，就可以根据沉淀物孔隙中二次母液的体积，估算出二次母液分离后糊剂层中残留的杂质量。糊剂再浆化的优化应结合置换洗涤、相分离所用设备以及对成品纯度水平的要求来考虑。
