从克罗恩病患者中分离出的一株分枝杆菌的体外抗菌药敏性。
In vitro antimicrobial susceptibility of a Mycobacterium sp. isolated from patients with Crohn's disease.
作者信息
Chiodini R J, Van Kruiningen H J, Thayer W R, Coutu J A, Merkal R S
出版信息
Antimicrob Agents Chemother. 1984 Dec;26(6):930-2. doi: 10.1128/AAC.26.6.930.
Abstract
The in vitro susceptibility of three strains of an unclassified Mycobacterium sp., isolated from three patients with Crohn's disease, to 23 antimicrobial agents was determined by a modified broth dilution method with 7H9 broth containing oleic acid-albumin-dextrose-catalase, Tween 80, and mycobactin J. All three strains were susceptible to streptomycin, viomycin, rifampin, clofazimine, cefazolin, amikacin, and kanamycin and resistant to p-aminosalicylic acid, cycloserine, 2-thiophenecarboxylic acid hydrazide, trimethoprim, diaminodiphenylsulfone, sulfamethoxazole, sulfadimethoxine, polymyxin B, metronidazole, neomycin, and carbenicillin. Variable results between strains were encountered with ethambutol, ethionamide, capreomycin, amoxicillin, and cephalothin.
摘要
从三名克罗恩病患者身上分离出的三株未分类分枝杆菌属菌株，采用改良肉汤稀释法，在含有油酸-白蛋白-葡萄糖-过氧化氢酶、吐温80和分枝杆菌素J的7H9肉汤中，测定了它们对23种抗菌剂的体外敏感性。所有三株菌株对链霉素、紫霉素、利福平、氯法齐明、头孢唑林、阿米卡星和卡那霉素敏感，对对氨基水杨酸、环丝氨酸、2-噻吩甲酰肼、甲氧苄啶、二氨基二苯砜、磺胺甲恶唑、磺胺二甲氧嘧啶、多粘菌素B、甲硝唑、新霉素和羧苄青霉素耐药。对于乙胺丁醇、乙硫异烟胺、卷曲霉素、阿莫西林和头孢噻吩，各菌株之间出现了不同的结果。
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