Bruchi S, Scattoni M, Buonocore G, Zani S, Bagnoli F
Boll Soc Ital Biol Sper. 1984 Sep 30;60(9):1703-8.
Determinations of serum calcium (Ca), calcitonin (CT) and parathyroid hormone (PTH) were carried out in mixed cord blood of 23 preterm infants. Gestational age ranged between 25 and 37 weeks. 17 of theme were vaginally delivered while 6 were delivered by emergency Caesarean section. 4 neonates died because of respiratory distress syndrome. The serum was stored at -30 degrees C until the determinations. Serum Ca levels were determined by spectrophotometry while CT and PTH levels by RIA (Immuno Nuclear Co). In cord serum the mean (M +/- SE) Ca,CT and PTH concentrations of all neonates examined were respectively: 9,9 +/- 0,6 mg/dl; 176 +/- 44 pg/ml and 1100 +/- 446 pg/ml. Serum values of CT and PTH in preterm newborns delivered by emergency Caesarean section were significantly higher than in those neonates vaginally delivered (CT: 302 +/- 115 vs 94 +/- 9 pg/ml; p less than 0.005) (PTH:2655 +/- 1857 vs 466 +/- 59 pg/ml; p less than 0.05). No differences were observed between serum CT and PTH levels in preterm neonates of different gestational age. Both CT and PTH serum concentrations were higher in neonates who died. In conclusion, the preterm neonate is able to secrete both peptides and to maintain Ca homeostasis; the mode of delivery likely affects the CT and PTH secretion; unexplainable high CT and PTH serum levels were detected in poor outcome preterm infants.
对23例早产儿的混合脐血进行了血清钙（Ca）、降钙素（CT）和甲状旁腺激素（PTH）测定。胎龄在25至37周之间。其中17例经阴道分娩，6例经急诊剖宫产分娩。4例新生儿因呼吸窘迫综合征死亡。血清在-30℃保存直至测定。血清钙水平采用分光光度法测定，CT和PTH水平采用放射免疫分析法（免疫核公司）测定。在脐血中，所有检查新生儿的血清Ca、CT和PTH平均（M±SE）浓度分别为：9.9±0.6mg/dl；176±44pg/ml和1100±446pg/ml。急诊剖宫产分娩的早产儿血清CT和PTH值显著高于经阴道分娩的新生儿（CT：302±115 vs 94±9pg/ml；p<0.005）（PTH：2655±1857 vs 466±59pg/ml；p<0.05）。不同胎龄的早产儿血清CT和PTH水平未观察到差异。死亡新生儿的CT和PTH血清浓度均较高。总之，早产儿能够分泌这两种肽并维持钙稳态；分娩方式可能影响CT和PTH分泌；在预后不良的早产儿中检测到无法解释的高CT和PTH血清水平。
