Schedewie H K, Odell W D, Fisher D A, Krutzik S R, Dodge M, Cousins L, Fiser W P
Pediatr Res. 1979 Jan;13(1):1-6. doi: 10.1203/00006450-197901000-00001.
Plasma parathormone (PTH) and calcium concentrations were measured in 309 specimens collected from 190 newborns during the first 7 days of life. The patient material consisted of 51 preterm, 130 term, and 9 postterm infants, including 22 infants of diabetic mothers (IDM), 38 infants with hypocalcemia, and 25 asphyxiated infants. PTH was detectable, although in low concentrations, in cord blood samples despite the presence of elevated calcium concentrations. Postpartum, PTH concentrations in term, appropriate for gestational age (AGA) infants remained low during the first 2 days of life; a significant (P less than 0.05) and sustained increase in plasma hormone levels was noted starting on day 3. PTH concentrations in IDM and preterm infants remained low for 3 days and a significant hormone increase did not occur until day 4. Hypocalcemia was common in IDM and asphyxiated infants; these infants accounted for two-thirds of all hypocalcemic infants. The profile of plasma calcium in IDM during the first week of life was different than that of any other group of infants. Plasma calcium concentrations remained depressed over this period of time and exhibited a temporary drop on day 4 accompanied by an increase in plasma PTH levels. Asphyxiated infants exhibited low plasma calcium concentrations, despite PTH levels that were significantly (P less than 0.007) higher than those of age-matched term AGA newborns.
对190名新生儿出生后7天内采集的309份样本进行了血浆甲状旁腺激素（PTH）和钙浓度检测。患者材料包括51名早产儿、130名足月儿和9名过期产儿，其中包括22名糖尿病母亲的婴儿（IDM）、38名低钙血症婴儿和25名窒息婴儿。尽管脐带血样本中钙浓度升高，但仍可检测到低浓度的PTH。产后，足月儿、适于胎龄（AGA）婴儿在出生后头2天的PTH浓度仍较低；从第3天开始，血浆激素水平出现显著（P<0.05）且持续的升高。IDM和早产儿的PTH浓度在3天内一直较低，直到第4天才出现显著的激素升高。低钙血症在IDM和窒息婴儿中很常见；这些婴儿占所有低钙血症婴儿的三分之二。IDM出生后第一周的血浆钙情况与其他任何一组婴儿都不同。在此期间，血浆钙浓度持续降低，并在第4天出现暂时下降，同时血浆PTH水平升高。窒息婴儿的血浆钙浓度较低，尽管其PTH水平显著（P<0.007）高于同龄足月儿AGA新生儿。
