[在含有N-亚硝基二甲胺前体的培养基中培养的大鼠肺细胞的生物学特性]
[Biological characteristics of rat lung cells cultured in a medium with N-nitrosodimethylamine precursors].
作者信息
Osin'kovskaia N D, Rubenchik B L
出版信息
Eksp Onkol. 1984;6(6):33-7.
PMID:6525976
Abstract
Lung tissue culture of 3-day old rats was cultivated in the presence of sodium nitrite, amidopyrine and combination of these substances with N-nitrosodimethylamine (NDMA). Each of these compounds produces specific changes in monolayer density, mitotic patterns and level of DNA synthesis in lung cell culture, which is considered to be convenient model for investigating cell response to the precursors of NDMA and to this carcinogen.
摘要
对3日龄大鼠的肺组织培养物在亚硝酸钠、氨基比林以及这些物质与N-亚硝基二甲胺（NDMA）的组合存在的情况下进行培养。这些化合物中的每一种都会在肺细胞培养物中引起单层密度、有丝分裂模式和DNA合成水平的特定变化，肺细胞培养物被认为是研究细胞对NDMA前体以及这种致癌物反应的便利模型。
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