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Identification of tumor promoters by their inhibitory effect on intercellular transfer of lucifer yellow.

作者信息

Budunova I V, Mittelman L A, Belitsky G A

机构信息

Laboratory of Carcinogen Screening Methods, All-Union Cancer Research Center of the AMS USSR, Moscow.

出版信息

Cell Biol Toxicol. 1989 Jan;5(1):77-89. doi: 10.1007/BF00141066.

DOI:10.1007/BF00141066
PMID:2493319
Abstract

The effect of the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein, teleocidin, anthralin, the Ca2+-ionophore A23187, butylated hydroxytoluene (BHT), dichlorodiphenyltrichloroethane (DDT) and phenobarbital (PB) on lucifer yellow transfer in cultures of SV-40-transformed Djungarian hamster fibroblasts was studied. TPA, mezerein, teleocidin, A23187, DDT and BHT exerted a strong inhibitory effect on cell-to-cell dye transfer. Anthralin uncoupled cells in 3 experiments out of 6. PB appeared to enhance lucifer yellow transfer. Sodium nitrite, a substance with unknown promoting activity, effectively uncoupled cells. All the promoters investigated had a reversible effect on the dye transfer. The value of the dye transfer method for promoter screening is discussed.

摘要

相似文献

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Identification of tumor promoters by their inhibitory effect on intercellular transfer of lucifer yellow.
Cell Biol Toxicol. 1989 Jan;5(1):77-89. doi: 10.1007/BF00141066.
2
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4
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5
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Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.

本文引用的文献

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Liver carcinogenesis: the role for some chemicals of an epigenetic mechanism of liver-tumour promotion involving modification of the cell membrane.肝癌发生：某些化学物质在通过细胞膜修饰促进肝肿瘤的表观遗传机制中所起的作用。
Food Cosmet Toxicol. 1981 Oct;19(5):577-83. doi: 10.1016/0015-6264(81)90508-3.
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Inhibition of intercellular communication between liver cells by the liver tumor promoter 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane.肝癌启动剂1,1,1-三氯-2,2-双（对氯苯基）乙烷对肝细胞间通讯的抑制作用
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Enhancement of tumor formation in mouse lung by dietary butylated hydroxytoluene.
基于细胞间通讯调节的具有促肿瘤或抑肿瘤活性化学物质的细胞培养分析。
Cell Biol Toxicol. 1994 Apr;10(2):71-116. doi: 10.1007/BF00756491.
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The effect of complete carcinogens on intercellular transfer of lucifer yellow in fibroblast culture.完全致癌物对成纤维细胞培养中荧光素黄细胞间转移的影响。
Cell Biol Toxicol. 1990 Jan;6(1):47-61. doi: 10.1007/BF00135026.
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Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.苯巴比妥和巴比妥对用N-双（2-羟丙基）亚硝胺处理的大鼠甲状腺肿瘤发生的促进作用
Carcinogenesis. 1982;3(10):1187-90. doi: 10.1093/carcin/3.10.1187.
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Disrupted communication between late-stage premalignant human colon epithelial cells by 12-O tetradecanoylphorbol-13-acetate.12-O-十四酰佛波醇-13-乙酸酯破坏晚期癌前人类结肠上皮细胞之间的通讯。
Cancer Res. 1982 Dec;42(12):5096-105.
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
J Biol Chem. 1982 Jul 10;257(13):7847-51.
8
International Commission for Protection against Environmental Mutagens and Carcinogens ICPEMC working paper 2/8: An evaluation of assay procedures for detection of tumor promotors.国际环境诱变剂和致癌物防护委员会（ICPEMC）工作文件2/8：肿瘤促进剂检测分析程序的评估
Mutat Res. 1982 May;98(3):377-87. doi: 10.1016/0165-1110(82)90041-0.
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Tumor promoters and the mechanism of tumor promotion.肿瘤促进剂与肿瘤促进机制。
Adv Cancer Res. 1980;32:1-74. doi: 10.1016/s0065-230x(08)60360-7.
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Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays.利用肝脏培养试验对遗传毒性和表观遗传致癌剂进行分类。
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