Shendrikova I A, Ermilov V B, Dikun P P
Vopr Onkol. 1984;30(6):91-6.
The study was concerned with a comparison of the effects of ethanol on N-nitrosodimethylamine (NDMA) synthesis from amidopyrine and sodium nitrite in rat stomach and on the same synthesis from dimethylamine (DMA) and sodium nitrite involving a 30-min incubation of their mixture at 37 degrees C in acid medium. Alcohol was found to inhibit DMA nitrosation thus lowering the yield of NDMA both in rat stomach and in a medium containing human gastric juice or glycine-hydrochloride buffer (pH = 3.4).
该研究关注乙醇对大鼠胃中氨基比林和亚硝酸钠合成N-亚硝基二甲胺（NDMA）的影响，以及对二甲胺（DMA）和亚硝酸钠在酸性介质中于37℃孵育30分钟合成NDMA的影响。结果发现，乙醇可抑制DMA的亚硝化作用，从而降低大鼠胃中以及含有人类胃液或甘氨酸 - 盐酸缓冲液（pH = 3.4）的介质中NDMA的产量。
