[The effect of alcohol on DMNA synthesis from its precursors in vivo and in vitro].

The study was concerned with a comparison of the effects of ethanol on N-nitrosodimethylamine (NDMA) synthesis from amidopyrine and sodium nitrite in rat stomach and on the same synthesis from dimethylamine (DMA) and sodium nitrite involving a 30-min incubation of their mixture at 37 degrees C in acid medium. Alcohol was found to inhibit DMA nitrosation thus lowering the yield of NDMA both in rat stomach and in a medium containing human gastric juice or glycine-hydrochloride buffer (pH = 3.4).