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正己烷尿液排泄量和加权暴露浓度。

n-Hexane urine elimination and weighted exposure concentration.

作者信息

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E

出版信息

Int Arch Occup Environ Health. 1984;55(1):33-41. doi: 10.1007/BF00378065.

DOI:10.1007/BF00378065
PMID:6526499
Abstract

The concentration of n-hexane in urine was determined in 30 subjects occupationally exposed to n-hexane (median value 59.6 mg/m3) in a shoe factory. The measurement of the substance was performed by means of a Hewlett-Packard 5880 gas chromatograph supplied with a Hewlett-Packard 5970 Mass Selective Detector. The analyses were performed by the head space method (constant volume method, after determination of the urine partition coefficient by the multiple phase equilibration method). The authors found a significant correlation between the n-hexane urine concentrations (microgram/l, Cu) and the n-hexane environmental concentrations (mg/m3, Ci) (r = 0.84; Cu = 0.0669 X Ci + 0.8396).

摘要

对一家鞋厂中30名职业性接触正己烷(中位值59.6毫克/立方米)的受试者的尿中正己烷浓度进行了测定。该物质的测量借助配备惠普5970质量选择检测器的惠普5880气相色谱仪进行。分析采用顶空法(定容法,通过多相平衡法测定尿液分配系数后)。作者发现尿中正己烷浓度(微克/升,Cu)与环境中正己烷浓度(毫克/立方米,Ci)之间存在显著相关性(r = 0.84;Cu = 0.0669×Ci + 0.8396)。

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n-Hexane urine elimination and weighted exposure concentration.正己烷尿液排泄量和加权暴露浓度。
Int Arch Occup Environ Health. 1984;55(1):33-41. doi: 10.1007/BF00378065.
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On the need of a sampling strategy in biological monitoring: the example of hexane exposure.论生物监测中抽样策略的必要性:以己烷暴露为例。
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2,5-Hexanedione excretion after occupational exposure to n-hexane.职业性接触正己烷后2,5 - 己二酮的排泄情况。

本文引用的文献

1
Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine.男性尿液中正己烷、环己烷及其异构体代谢物的鉴定。
Toxicol Appl Pharmacol. 1980 Apr;53(2):220-9. doi: 10.1016/0041-008x(80)90422-6.
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Biological monitoring of persons exposed to methanol vapours.对接触甲醇蒸气人员的生物监测。
Int Arch Occup Environ Health. 1981;48(3):257-71. doi: 10.1007/BF00405613.
3
Measurement of the urinary metabolites of N-hexane, cyclohexane and their isomers by gas chromatography.采用气相色谱法测定正己烷、环己烷及其异构体的尿代谢物。
Br J Ind Med. 1988 Feb;45(2):133-6. doi: 10.1136/oem.45.2.133.
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Biological monitoring of workers exposed to acetone in acetate fibre plants.醋酸纤维厂接触丙酮工人的生物监测。
Br J Ind Med. 1992 Sep;49(9):654-7. doi: 10.1136/oem.49.9.654.
Int Arch Occup Environ Health. 1981;48(1):99-106. doi: 10.1007/BF00405936.
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[The measurement of the solubility coefficients of aeriforms in the blood or other solvent liquids. I. The methods].
G Ital Med Lav. 1982 Nov;4(6):251-61.
5
Biological monitoring of occupational exposure to methyl ethyl ketone by means of urinalysis for methyl ethyl ketone itself.
Int Arch Occup Environ Health. 1982;50(2):131-7. doi: 10.1007/BF00378075.
6
Experimental human exposure to n-Hexane. Study of the respiratory uptake and elimination, and of n-Hexane concentrations in peripheral venous blood.
Int Arch Occup Environ Health. 1982 Feb;49(3-4):251-63. doi: 10.1007/BF00377934.
7
A study on biological monitoring of n-hexane exposure.一项关于正己烷暴露生物监测的研究。
Int Arch Occup Environ Health. 1983;51(3):253-60. doi: 10.1007/BF00377756.
8
[Measurement of the coefficient of solubility of airborne substances in blood. II. Solvents of wide industrial use].
G Ital Med Lav. 1983 Mar;5(2):49-63.
9
Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK.暴露于不同浓度正己烷及其与甲苯或甲乙酮混合物的大鼠尿液中正己烷代谢物的变化。
Int Arch Occup Environ Health. 1983;53(1):1-8. doi: 10.1007/BF00406172.
10
n-Hexane metabolism in occupationally exposed workers.职业暴露工人中正己烷的代谢
Br J Ind Med. 1984 Nov;41(4):533-8. doi: 10.1136/oem.41.4.533.