Perbellini L, Brugnone F, Faggionato G
Br J Ind Med. 1981 Feb;38(1):20-6. doi: 10.1136/oem.38.1.20.
Environmental exposure to commercial hexane (n-hexane, 2-methylpentane, and 3-methylpentane) was tested in several work places in five shoe factories by taking three grap-air samples during the afternoon shift. Individual exposure ranges were 32-500 mg/m3 for n-hexane, 11-250 mg/m3 for 2-methylpentane, and 10-204 mg/m3 for 3-methylpentane. The metabolites of commercial hexane in the urine of 41 workers were measured at the end of the work shift. 2-Hexanol, 2,5-hexanedione, 2,5-dimethylfuran, and gamma-valerolactone were found as n-hexane metabolites and 2-methyl-2-pentanol and 3-methyl-2-pentanol as 2-methylpentane and 3-methylpentane metabolites. The presence of metabolites in the urine was correlated with occupational exposure to solvents. n-Hexane exposure was correlated more positively with 2-hexanol and 2,5-hexanedione than with 2,5-dimethylfuran and gamma-valerolactone. A good correlation was also found between total n-hexane metabolites and n-hexane exposure. 2-Methyl-2-pentanol and 3-methyl-2-pentanol were highly correlated with 2-methylpentane and 3-methylpentane exposure. The results suggest that the urinary excretion of hexane metabolites may be used for monitoring occupational exposure to n-hexane and its isomers.
通过在下午班次期间采集三个工作场所空气样本，对五家制鞋厂的多个工作地点进行了商业己烷（正己烷、2-甲基戊烷和3-甲基戊烷）的环境暴露测试。正己烷的个体暴露范围为32-500毫克/立方米，2-甲基戊烷为11-250毫克/立方米，3-甲基戊烷为10-204毫克/立方米。在工作班次结束时测量了41名工人尿液中商业己烷的代谢产物。发现2-己醇、2,5-己二酮、2,5-二甲基呋喃和γ-戊内酯为正己烷代谢产物，2-甲基-2-戊醇和3-甲基-2-戊醇为2-甲基戊烷和3-甲基戊烷代谢产物。尿液中代谢产物的存在与职业性溶剂暴露相关。正己烷暴露与2-己醇和2,5-己二酮的相关性比与2,5-二甲基呋喃和γ-戊内酯的相关性更强。总正己烷代谢产物与正己烷暴露之间也发现了良好的相关性。2-甲基-2-戊醇和3-甲基-2-戊醇与2-甲基戊烷和3-甲基戊烷暴露高度相关。结果表明，己烷代谢产物的尿排泄可用于监测职业性正己烷及其异构体暴露。
