职业性接触正己烷后2,5 - 己二酮的排泄情况。
2,5-Hexanedione excretion after occupational exposure to n-hexane.
作者信息
Ahonen I, Schimberg R W
机构信息
Tampere Regional Institute of Occupational Health, Finland.
出版信息
Br J Ind Med. 1988 Feb;45(2):133-6. doi: 10.1136/oem.45.2.133.
Abstract
The urinary excretion of the n-hexane metabolite 2,5-hexanedione (HD) was determined in four shoe factory workers during four workingdays that were preceded by four free days and followed by two free days. The correlation between excretion of HD and the n-hexane concentrations in the workroom air was evaluated. The air concentrations of n-hexane and those of acetone, toluene, and other organic solvents were monitored with charcoal tubes. All the urine from each worker was collected at freely chosen intervals during the experimental period and the following two free days. The samples were analysed by gas chromatography. The relative excretion of HD increased as the exposure to n-hexane increased, although it seemed that HD accumulated progressively in the body at the highest n-hexane concentrations and at higher total solvent concentrations.
摘要
在四名鞋厂工人中，于四个工作日期间测定了正己烷代谢物2,5 - 己二酮（HD）的尿排泄量，这四个工作日之前有四个休息日，之后有两个休息日。评估了HD排泄量与工作场所空气中正己烷浓度之间的相关性。用活性炭管监测正己烷以及丙酮、甲苯和其他有机溶剂的空气浓度。在实验期间以及随后的两个休息日，以自由选择的时间间隔收集每位工人的所有尿液。通过气相色谱法对样品进行分析。尽管在最高正己烷浓度和较高总溶剂浓度下，HD似乎在体内逐渐积累，但随着正己烷暴露量的增加，HD的相对排泄量也增加。
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