Itoh K, Kondoh H, Hayasaki M, Noda K
Jpn J Antibiot. 1984 Dec;37(12):2343-8.
Excretion of ceftriaxone (Ro 13-9904, CTRX) into female genital organs was studied by determining its concentration in the dead space exudate of the patients who received radical hysterectomy due to uterocervical cancer. Data analysis was performed by the three-compartment model. The serum peak level of CTRX in the cubital vein was 177.74 micrograms/ml 1 hour after the initiation of intravenous drip infusion for 1 hour with 1 g. The concentration of CTRX in the exudate of pelvic dead space reached a peak of 62.75 micrograms/ml 4.61 hours after the start of administration and still showed a very high level of 25 micrograms/ml at 24 hours. The AUC of the excretion into the exudate of pelvic dead space was 1,432.43 micrograms X hr/ml. These results indicate that CTRX is a clinically useful drug, being excreted into the exudate of pelvic dead space favorably.
通过测定因子宫颈癌接受根治性子宫切除术患者死腔渗出液中的浓度，研究了头孢曲松（Ro 13 - 9904，CTRX）在女性生殖器官中的排泄情况。采用三室模型进行数据分析。以1g静脉滴注1小时后，肘静脉中CTRX的血清峰值水平在给药1小时后为177.74微克/毫升。给药开始4.61小时后，盆腔死腔渗出液中CTRX的浓度达到峰值62.75微克/毫升，24小时时仍显示出25微克/毫升的非常高的水平。盆腔死腔渗出液排泄的AUC为1432.43微克·小时/毫升。这些结果表明CTRX是一种临床有用的药物，能很好地排泄到盆腔死腔渗出液中。
