Muramatsu M, Kakita K, Nakagawa K, Kuriyama K
Jpn J Pharmacol. 1978 Apr;28(2):259-68. doi: 10.1254/jjp.28.259.
Effects of taurine (2-aminoethanesulfonic acid) on the uptake and release of 14C-acetylcholine (14C-ACh) and 3H-norepinephrine (3H-NE) in the superior cervical ganglion and cerebral cortex of the rat were studied. Taurine suppressed high potassium evoked release of 14C-ACh and 3H-NE from the rat superior cervical ganglia and cerebral cortical slices, while the drug did not modify per se the uptake and unstimulated (spontaneous) release of 14C-ACh and 3H-NE in these tissues. Furthermore, taurine inhibited the release of 3H-NE from the crude synaptosomal (P2) fraction of the rat brain without affecting the uptake. These results suggest that taurine may act as a modulator of neuronal activity, possibly by stabilizing excitable membrane and by suppressing the release of neurotansmitter at synapses.
研究了牛磺酸（2-氨基乙磺酸）对大鼠颈上神经节和大脑皮层中14C-乙酰胆碱（14C-ACh）和3H-去甲肾上腺素（3H-NE）摄取与释放的影响。牛磺酸抑制了高钾诱发的大鼠颈上神经节和大脑皮层切片中14C-ACh和3H-NE的释放，而该药物本身并未改变这些组织中14C-ACh和3H-NE的摄取及未受刺激（自发）释放。此外，牛磺酸抑制了大鼠脑粗突触体（P2）组分中3H-NE的释放，而不影响摄取。这些结果表明，牛磺酸可能作为神经元活动的调节剂，可能是通过稳定可兴奋膜以及抑制突触处神经递质的释放来发挥作用。
